Lipid metabolism gene-wide profile and survival signature of lung adenocarcinoma
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RESEARCH
Open Access
Lipid metabolism gene-wide profile and survival signature of lung adenocarcinoma Jinyou Li1,2† , Qiang Li3†, Zhenyu Su1, Qi Sun1, Yong Zhao1, Tienan Feng4, Jiayuan Jiang4, Feng Zhang1* and Haitao Ma2*
Abstract Background: Lung cancer has high morbidity and mortality across the globe, and lung adenocarcinoma (LUAD) is the most common histologic subtype. Disordered lipid metabolism is related to the development of cancer. Analysis of lipid-related transcriptome helps shed light on the diagnosis and prognostic biomarkers of LUAD. Methods: In this study, expression analysis of 1045 lipid metabolism-related genes was performed between LUAD tumors and normal tissues derived from the Cancer Genome Atlas Lung Adenocarcinoma (TCGA-LUAD) cohort. The interaction network of differentially expressed genes (DEGs) was constructed to identify the hub genes. The association between hub genes and overall survival (OS) was evaluated and formed a model to predict the prognosis of LUAD using a nomogram. The model was validated by another cohort, GSE13213. Results: A total of 217 lipid metabolism-related DEGs were detected in LUAD. Genes were significantly enriched in glycerophospholipid metabolism, fatty acid metabolic process, and eicosanoid signaling. Through network analysis and cytoHubba, 6 hub genes were identified, including INS, LPL, HPGDS, DGAT1, UGT1A6, and CYP2C9. High expression of CYP2C9, UGT1A6, and INS, and low expressions of DGAT1, HPGDS, and LPL, were associated with worse overall survival for 1925 LUAD patients. The model showed that the high-risk score group had a worse OS, and the validated cohort showed the same result. Conclusions: In this study, a signature of 6 lipid metabolism genes was constructed, which was significantly associated with the diagnosis and prognosis of LUAD patients. Thus, the gene signature can be used as a biomarker for LUAD. Keywords: Diagnosis, Hub genes, Lipid metabolism, Lung adenocarcinoma, Nomogram, Prognosis, Signature
Background Lung cancer is the most commonly diagnosed cancer (11.6% of the total cases) and the leading cause of cancerrelated death (18.4% of the total cancer-related deaths) in the world [1]. Among lung cancer subtypes, adenocarcinoma is the most common histologic subtype of lung cancer in both men and women [2]. In a study published in 2020 * Correspondence: [email protected]; [email protected] † Jinyou Li and Qiang Li contributed equally to this work. 1 Department of Thoracic Surgery, Affiliated Hospital of Jiangnan University, Wuxi 214000, China 2 Department of Thoracic Surgery, First Affiliated Hospital of Soochow University, Suzhou 215006, China Full list of author information is available at the end of the article
in China, it was reported that in the recent 10 years, the percentage of lung adenocarcinoma (LUAD) increased significantly with a decrease in squamous carcinoma [3]. The increasing incidence of lung adenocarcinoma (LUAD) has also been reported to be associated with air pollutionrelated factors [4–6]. In previous studies, i
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