Lipid Profile in Children With Thalassemia: A Prospective Observational Study From Eastern India
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ALICE JEBA J,1* SENTHIL KUMAR S2 AND SHIVAPRAKASH SOSALE3
From 1Department of Pediatric Physiotherapy and
3Department of Pediatrics, NRR Hospital, Chikkabanavara,
Bangalore, Karnataka, India; and 2Department of Physiotherapy, Saveetha University, Thandalam, Chennai, India. *[email protected]
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Lipid Profile in Children With Thalassemia: A Prospective Observational Study From Eastern India
high TC:HDL ratio are pro-atherogenic factors, which help in cardiac risk stratification and prognostication [6,7]. Pediatric data regarding lipid profile in thalassemia is limited. Our primary objective was to evaluate abnormalities in lipid profile in children with thalassemia.
This was a prospective observational study to evaluate abnormalities in lipid profile in 50 children with transfusion dependent thalassemia. Dyslipidemia characterized by high triglycerides, low high density lipoprotein (HDL), and high total cholesterol: HDL ratio was noted. These pro atherogenic risk factors may be lead to significant cardiovascular morbidity in these patients. Keywords: Atherosclerosis, Co-morbidity, E beta thalassemia, Outcome.
Life expectancy and quality of life of beta-thalassemia patients have improved in recent years. However, non-siderotic complications are known to cause significant morbidity in these patients with beta-thalassemia. In recent years, many studies have shown risk of developing subclinical atherosclerosis in beta-thalassemia patients. Strong association of abnormal serum lipid levels [low total cholesterol (TC) and (high density lipoprotein) HDL-cholesterol, high triglycerides (TG) and TC: HDL ratio) with premature atherosclerosis have been noted in children with beta thalassemia [2-5]. Low HDL - cholesterol and
INDIAN PEDIATRICS
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