A Study to Assess and Correlate Serum Lipid Profile with Reaction Time in Healthy Individuals
- PDF / 186,902 Bytes
- 6 Pages / 595.276 x 790.866 pts Page_size
- 57 Downloads / 172 Views
ORIGINAL RESEARCH ARTICLE
A Study to Assess and Correlate Serum Lipid Profile with Reaction Time in Healthy Individuals Sagar Dua1 • Praveen Singh1 • Sarama Saha1
Received: 4 May 2019 / Accepted: 9 September 2019 Ó Association of Clinical Biochemists of India 2019
Abstract Dyslipidaemia, metabolic syndrome, diabetes mellitus and arterial hypertension contribute to the risk of cognitive disorder and dementia. However very few and conflicting results are available with respect to the impact of lipoprotein ratios on cognitive functions in healthy individuals. Therefore, this study was aimed to investigate the association of lipid profile and its ratios with reaction time in young healthy individuals. 89 individuals (54 male and 35 female) with mean age of 31.20 ± 3.19 years were selected for this observational study conducted at AIIMS Rishikesh and written consent was obtained. TC, TG, HDL were measured by semi auto analyzer following the manufacturers’ instruction and LDL was calculated by Friedewald formula. Reaction time (simple and choice reaction time) was assessed using a software package, Deary–Liewald reaction time task. Association of various parameters was calculated by pearson’s correlation coefficient using SPSS version 23.0. Reaction time showed significant negative association with BMI (r = - 0.323, p = 0.002) in total study participants as well as with TG (r = - 0.440, p = 0.008) and TG/HDL (r = - 0.402, p = 0.025) in female individuals. From this study, it could be concluded that TG/HDL ratio, the superlative predictor of concomitant presence of cardiovascular disease, insulin resistance and metabolic syndrome may be considered as a biomarker for assessment of cognitive function in young healthy female individuals.
& Sarama Saha [email protected] 1
Department of Biochemistry, AIIMS, Rishikesh, India
Keywords Simple reaction time Dyslipidaemia Lipid ratio Choice reaction time Deary–Liewald reaction time task
Introduction Cerebral lipids specially cholesterol, play a crucial role in maintaining the homeostasis of neuronal membrane and synaptic function. Dyslipidaemia, is a metabolic abnormality leading to a persistent increase in the plasma concentration of total cholesterol (TC) and triglycerides (TG). It is a common cause of morbidity all over the world, and the most common form is hypercholesterolemia. It is estimated that hypercholesterolemia is responsible for 2.6 million (4.5%) deaths in the world. [1]. It has been documented that an increased level of total cholesterol and lowdensity lipoproteins contribute to the risk of mental disorders towards later part of life [2]. Dyslipidemia leads to increase in level of cerebral myoinositol elevations in middle age. A recent study showed that increased myo-inositol affect negatively to memory performance in someone’s middle of the age. Increase in myo-inositol occur early in the neurodegenerative process and predict cognitive decline in most of the conditions [3]. Moreover, in mild-to-moderate Alzheimer’s disease, plasma TG and HDL cho
Data Loading...
