Liver Immunology Principles and Practice
The third edition of this acclaimed work provides clinicians and investigators with a wealth of state-of-the-art information that will lead to fresh approaches in thinking about liver physiology and liver diseases. Developed by a panel of renowned i
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Liver Immunology Principles and Practice Third Edition
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Liver Immunology
M. Eric Gershwin • John M. Vierling Atsushi Tanaka • Michael P. Manns Editors
Liver Immunology Principles and Practice Third Edition
Editors M. Eric Gershwin Division of Rheumatology, Allergy and Clinical Immunology The University of California School of Medicine Davis, CA USA Atsushi Tanaka Department of Medicine Teikyo University School of Medicine Itabashi Tokyo Japan
John M. Vierling Departments of Medicine and Surgery Baylor College of Medicine Houston, TX USA Michael P. Manns President Hannover Medical School Hannover Germany
ISBN 978-3-030-51708-3 ISBN 978-3-030-51709-0 (eBook) https://doi.org/10.1007/978-3-030-51709-0 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
The Editors and Authors dedicate with gratitude and respect this third edition of Liver Immunology: Principles and Practice to the memory and legacy of our dear friend and colleague, Edward L. Krawitt, M.D. Ed was internationally recognized for his contributions to the scientific understanding of autoimmune liver diseases, especially autoimmune hepatitis. His patients admired and esteemed him as a consummate clinician, who always sought better diagnostic and therapeutic options for their care. His professionalism, scientific rigor, depth of knowledge, clinical acumen, and humble style contributed to his success as an educator, mentor, and administrator. All of us who were privileged to know and work with him cherished his warmth, friendship, and enthusiasm for life.
Preface
The Babylonians appreciated the liver as a vital organ in the nineteenth century B.C., but today, some 4000 years later,
