LncRNA-MALAT1 is a promising biomarker for prognostic evaluation of tongue squamous cell carcinoma
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HEAD AND NECK
LncRNA‑MALAT1 is a promising biomarker for prognostic evaluation of tongue squamous cell carcinoma Yuqian Hu1 · Linlin Zheng1 · Jinhui Zhang1 · Yue Shen1 · Xiaoyan Zhang2 · Lijuan Lin1 Received: 21 February 2020 / Accepted: 27 April 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose MALAT1 is recognized as an oncogenic lncRNA in various malignancies. Here, the authors aim to explore the association of MALAT1 expression and prognostic implication in tongue squamous cell carcinoma (SCC). Methods The tongue tissues of 128 tongue SCC cases satisfying strict follow-up criteria and 28 normal cases were subjected to qRT-PCR assay for monitoring MALAT1 expression. Chi-square test was applied to explore the correlation between MALAT1 expression and clinicopathological features of tongue SCC. Kaplan–Meier analysis was used to calculate survival rates. Cox proportional hazard analysis was adopted to analyze the relationship between prognostic factors and patient survival. Results The expression of MALAT1 was upregulated in tongue SCC, compared to normal tongue tissues. The expression level of MALAT1 was correlated to differentiation and stage of tongue SCC, and high MALAT1 expression was associated with low disease-free survival and overall survival rates. Moreover, advanced tongue SCC patients with high MALAT1 level had lower disease-free survival and decreased overall survival rate than patients with low MALAT1 level. These results revealed that MALAT1 overexpression can be considered as a significant prognostic factor to independently predict the disease-free survival and overall survival rate of tongue SCC. Conclusions The expression level of MALAT1 is closely related with progression of tongue SCC. Furthermore, MALAT1 can serve as an independent biomarker for prognostic evaluation of tongue SCC. Keywords LncRNA · MALAT1 · Tongue SCC · Prognosis · Survival analysis
Introduction Oral cavity cancer with high morbidity and mortality in the past decades has been increasingly concerned [1]. The tongue is the most common occurrence site of oral cavity cancer. Patients with tongue squamous cell carcinoma (SCC) Yuqian Hu and Linlin Zheng are co-first author for this manuscript. * Xiaoyan Zhang [email protected] * Lijuan Lin [email protected] 1
Institute of Molecular Medicine, Medical College of Eastern Liaoning University, Dandong 118000, China
Department of Pathology, Fifth People’s Hospital of Shenyang City, Shenyang Tumor Hospital, Shenyang 110023, China
2
have an obvious poor prognosis than patients with other oral cavity, and SCC patients always suffer from serious oral dysfunction, such as speech and swallowing difficulties [2]. After subtotal or total glossectomy, the patient’s orthobiosis cannot be satisfied [3]. Although some novel therapy technologies have been developed and proper treatment can be administrated to patients with tongue SCC, it is inevitable that patients with tongue SCC often suffer from a high risk of emerging tumors recurrence and s
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