Longitudinal bone microarchitectural changes are best detected using image registration
- PDF / 1,016,438 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 49 Downloads / 207 Views
ORIGINAL ARTICLE
Longitudinal bone microarchitectural changes are best detected using image registration T.D. Kemp 1,2 & C.M.J. de Bakker 2,3 & L. Gabel 2,3 & D.A. Hanley 2 & E.O. Billington 2 & L.A. Burt 2,3 & S.K. Boyd 1,2,3 Received: 17 March 2020 / Accepted: 4 May 2020 # International Osteoporosis Foundation and National Osteoporosis Foundation 2020
Abstract Summary Longitudinal studies of bone using high-resolution medical imaging may result in non-physiological measurements of longitudinal changes. In this study, we determined that three-dimensional image processing techniques best capture realistic longitudinal changes in bone density and should therefore be used with high-resolution imaging when studying bone changes over time. Introduction The purpose of this study was to determine which longitudinal analysis technique (no registration (NR), slice-match (SM) registration, or three-dimensional registration (3DR)) produced the most realistic longitudinal changes in a 3-year study of bone density and structure using high-resolution peripheral quantitative computed tomography (HR-pQCT). Methods We assessed HR-pQCT scans of the distal radius and tibia for men and women (N = 40) aged 55–70 years at baseline and 6, 12, 24, and 36 months. To evaluate which longitudinal analysis technique (NR, SM, or 3DR) best captured physiologically reasonable 3-year changes, we calculated the standard deviation of the absolute rate of change in each bone parameter. The data were compared between longitudinal analysis techniques using repeated measures ANOVA and post hoc analysis. Results As expected, both SM and 3DR better captured physiological longitudinal changes than NR. At the tibia, there were no differences between SM and 3DR; however, at the radius where precision was lower, 3DR produced better results for total bone mineral density. Conclusions At least SM or 3DR should be implemented in longitudinal studies using HR-pQCT. 3DR is preferable, particularly at the radius, to ensure that physiological changes in bone density are observed. Keywords 3D registration . Bone density . Bone microarchitecture . HR-pQCT . Least significant change . Longitudinal analysis
Introduction Recent developments in high-resolution imaging are providing important insight into microarchitecture, mineralization, and biomechanics of bone tissue. Specifically, highresolution peripheral quantitative computed tomography (HR-pQCT) is a non-invasive and low-radiation imaging * S.K. Boyd [email protected] 1
Department of Mechanical and Manufacturing Engineering, Schulich School of Engineering, University of Calgary, Calgary, Canada
2
McCaig Institute for Bone and Joint Health, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6, Canada
3
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Canada
method used to assess bone microarchitecture and volumetric bone mineral density at the peripheral sites of the radius and tibia with an isotropic voxel size of 82 μm or 61 μm, depending on the sca
Data Loading...
