Lower risk of pancreatitis with statins
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Lower risk of pancreatitis with statins Statin therapy has been associated with pancreatitis in observational studies; however, a meta-analysis published in JAMA indicates that, in patients with normal or mildly elevated triglyceride levels, statins may actually reduce pancreatitis risk. The analysis included published and unpublished data on incident pancreatitis for randomised controlled trials of statins (21 trials; n = 153 414) and fibrates (7 trials; n = 40 162) which had involved > 1000 patients and follow-up durations of > 1 year. Combined results for the 21 statin trials showed a statistically significant reduction in the risk of pancreatitis (risk ratio 0.79; 95% CI 0.65, 0.95; p = 0.01). When analysed separately, a significant reduction was seen in the 16 trials (n = 113 800) comparing statins with placebo or standard care (0.77; 0.62, 0.97; p = 0.03) but not the five dose-comparison trials of statins (0.82; 0.59, 1.12). No significant association was seen between fibrate therapy and pancreatitis (1.39; 1.00, 1.95; p = 0.053). The researchers caution that the findings are not necessarily generalisable to patients with moderate-tosevere hypertriglyceridaemia,* who are at higher risk of developing pancreatitis, as they tended to be excluded from the clinical trials analysed. * baseline triglyceride levels ≥ 400–500 mg/dL Preiss D, et al. Lipid-modifying therapies and risk of pancreatitis: a meta-analysis. JAMA: the Journal of the American Medical Association 308: 804-11, No. 8, 22 Aug 2012. Available from: URL: http://dx.doi.org/10.1001/ 803076440 jama.2012.8439
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Reactions 1 Sep 2012 No. 1417
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