Statins
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Elevated aminotransferase levels: 24 case reports In a prospective study of 515 elderly patients, who received treatment with statin between January 2014 to December 2015, 24 patients (20 men and 4 women) in their 80s or 90s were described, who developed elevated ALT levels and elevated AST levels during treatment with simvastatin (6 patients), fluvastatin (8 patients), pravastatin (4 patients), rosuvastatin (1 patient) or atorvastatin (5 patients) for hypercholesterolaemia [routes not stated; not all doses stated]. The patients, who had several unspecified comorbidities along with hypercholesterolaemia and had been on several unspecified medications, started receiving once daily doses of simvastatin (standard dose 40mg), fluvastatin 40mg, pravastatin 40mg, rosuvastatin 10mg or atorvastatin (standard dose 20mg). Out of the 24 patients, 5 patients were heavy alcohol drinkers, 11 patients were mild to moderate alcohol drinkers and 8 patients had no history of alcohol drinking. Prior to the initiation of the treatment with statins, liver biochemistries revealed ALTs in the range of 10–34 IU/L and ASTs in the range of 11–25 IU/L. Within 2 weeks to 6 months from the initiation of statin treatment, repeat liver biochemistries revealed elevated levels of ALT (34–1017 IU/L) and AST (37–696 IU/L). The elevation was mild in 15 patients, moderate in 7 patients and severe in 2 patients. Consequently, the patients with moderate or severe elevation of aminotransferases discontinued treatment with statin. Following discontinuation, ALTs and ASTs recovered within 2 weeks to 3 months [not all outcomes stated]. Guo M, et al. A prospective study of hepatic safety of statins used in very elderly patients. BMC Geriatrics 19: 16 Dec 2019. Available from: URL: https://doi.org/10.1186/ 803499045 s12877-019-1361-2
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Reactions 5 Sep 2020 No. 1820
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