Lymph node metastasis in suprasternal space and intra-infrahyoid strap muscle space from papillary thyroid carcinoma
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(2020) 49:64
ORIGINAL RESEARCH ARTICLE
Open Access
Lymph node metastasis in suprasternal space and intra-infrahyoid strap muscle space from papillary thyroid carcinoma Qianqian Yuan1, Jinxuan Hou1, Yiqin Liao1, Lewei Zheng1, Fang Lu1, Kun Wang2 and Gaosong Wu1*
Abstract Background: This study was performed to evaluate the clinicopathologic characteristics of Lymph Node metastasis between investing layer of Cervical fascia and deep fascia of infrahyoid strap Muscles (LNCM) in papillary thyroid carcinoma (PTC). Methods: Retrospective review of patients with PTC who underwent thyroidectomy and central compartment neck dissection (CND) from January 2016 to January 2018 was performed in two tertiary referral academic medical centers. A total of 2104 consecutive patients with PTC who underwent thyroidectomy and CND were included in the retrospective review. The LNCM was resected as a separate specimen by the surgeon and the clinicopathologic characteristics of the patients were recorded. Multivariate logistic regression analysis was performed to identify risk factors for LNCM metastasis. Results: Of 2104 PTC patients, 451 patients (21.4%) had lymph nodes in the LNCM. Among them, 68 (15.1%) cases were confirmed to be positive in the LNCM. In total, the metastasis rate of LNCM in PTC patients was 3.2% (68/ 2104). Univariate analysis revealed that the metastasis of LNCM were more likely to have a primary site in the inferior pole, extrathyroidal extension (ETE), central cervical metastasis, level III and level IV metastasis. Multivariate analysis further showed tumor location in the inferior pole, ETE, level III and level IV metastasis conferred a significantly increased odds ratio for LNCM metastasis. Conclusion: Attention should be paid to the lymph tissue in the LNCM for PTC patients, especially in presence of a primary site in the inferior pole, ETE, level III and level IV metastasis. Keywords: Thyroid carcinoma, Surgery, Central compartment neck dissection, Recurrence, Suprasternal space
Introduction Patients with papillary thyroid carcinoma (PTC) have a favorable prognosis with central neck locoregional recurrence varying from 0 to 20% [1]. The goal of a prophylactic or therapeutic central compartment neck dissection (pCND or tCND) is to decrease the incidence of local recurrence by removing all lymphatic tissue within the levels VI and * Correspondence: [email protected] 1 Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, Hubei, People’s Republic of China 430071 Full list of author information is available at the end of the article
VII compartments, which are generally the first and the most commonly involved with metastasis [2]. For patients without evidence of lymph node metastasis on preoperative evaluation, the additive value of a pCND at the time of thyroidectomy is controversial. Some authors advocate pCND, considering high rate (24–88%) of occult metastatic nodal disease in cN0 PTC [1], while other authors consider that there is no high-level evid
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