Papillary carcinoma thyroid with metastasis to ectopic cervical thymus
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Papillary carcinoma thyroid with metastasis to ectopic cervical thymus Mushtaque et al.
Mushtaque et al. World Journal of Surgical Oncology 2011, 9:22 http://www.wjso.com/content/9/1/22 (18 February 2011)
Mushtaque et al. World Journal of Surgical Oncology 2011, 9:22 http://www.wjso.com/content/9/1/22
CASE REPORT
WORLD JOURNAL OF SURGICAL ONCOLOGY
Open Access
Papillary carcinoma thyroid with metastasis to ectopic cervical thymus Majid Mushtaque1*, Sameer H Naqash1, Ajaz A Malik1, Rayees A Malik2, Samina A Khanday3, Parwez S Khan1
Abstract Papillary carcinoma of thyroid is the most common type of thyroid neoplasm which is usually confined to the thyroid and tends to metastasize to regional lymph nodes. Distant metastasis occur in up to 15% of cases. Thymic metastasis from any malignant carcinoma is extremely rare with only four cases reported in medical literature. We report a case of papillary carcinoma of thyroid metastasizing to ectopic cervical thymus which has not been previously reported. Introduction/Background Papillary thyroid carcinoma is the most common neoplasm in the thyroid gland and accounts for about 70% of all thyroid carcinomas. This tumor peaks in the third or fourth decades of life, with female to male ratio ranging from 1.6:1 to 3:1 [1]. Thyroid cancers, especially papillary carcinoma, are more often found in patients with a history of external irradiation. Papillary carcinoma of thyroid may be sub clinical or may be present with asymptomatic thyroid mass or a nodule. Other symptoms like pain, difficulty breathing or swallowing, stridor, vocal cord paralysis, haemoptysis, rapid enlargement are rare. It commonly metastasizes to regional lymph nodes, but at the time of diagnosis, 10-15% of patients have distant metastases to the bones and lungs [2]. Other rare sites of distant metastasis are the brain, liver, and skin. [3] The thymus is an important organ involved in cellmediated immunological function, and to our knowledge, there has been only one case of papillary thyroid carcinoma with metastasis to thymus reported [4]. We report a case of papillary carcinoma of thyroid metastasizing to ectopic cervical thymus which has not been previously reported. Case Presentation A 42 year old female presented with a progressively enlarging painless swelling in the anterior part of the * Correspondence: [email protected] 1 Department of Surgery, Sheri Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir,190011, India Full list of author information is available at the end of the article
neck since 1 year. The only complaint was that of disfigurement. There was no other significant history. On examination, a single swelling was present in anterior neck, 13 × 8 cm in size, irregular in shape, extending vertically from thyroid cartilage above to supra sternal notch below and between two sternomastoid muscles. It was firm in consistency, moved freely with deglutition and had ill defined lower margin. There was no cervical lymphadenopathy. Examination of respiratory, cardio
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