Macular and choroidal thicknesses in a healthy Hispanic population evaluated by high-definition spectral-domain optical
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nternational Journal of Retina and Vitreous Open Access
ORIGINAL ARTICLE
Macular and choroidal thicknesses in a healthy Hispanic population evaluated by high‑definition spectral‑domain optical coherence tomography (SD‑OCT) Diana A. Cortés1,2 , Daniela Roca1,2, Pedro Iván Navarro1,3 and Francisco J. Rodríguez1,2*
Abstract Purpose: To report normal values of macular and choroidal thickness obtained from a healthy Hispanic population using Optovue (Optovue Inc, Freemont CA, USA) spectral domain optical coherence tomography (SD-OCT). Design: Observational, cross-sectional, correlation study. Methods: A total of 290 eyes (145 healthy subjects) were included; 69% of subjects were female. The median age was 39 ± 29 years (IQR), with a range between 18 and 89 years. The study sample was stratified into three age groups: Group 1, 18–40 years (50.3%), Group 2, 41–60 years (30.7%), and Group 3, older than 61 years (19%). Central macular, perifoveal (inner quadrants), and parafoveal (outer quadrants) thicknesses were estimated. In addition, central and peripheral choroidal thicknesses were estimated. Data analysis was performed to calculate the standardized mean difference according to the variance (Student’s t-test) and its differences with Epidat 4.1. Results: Median macular central thickness was 250 ±30 µm (IQR) with Optovue. Median central choroidal thickness was 263 ± 48 µm (IQR). Median central choroidal thickness was greater than mean peripheral thickness. Macular evaluation showed a statistically significant difference in central, perifoveal, and parafoveal thicknesses, with lower values being recorded for the study sample compared with the manufacturer’s data. Conclusions: SD-OCT has become a useful tool to obtain high-resolution images of the macula and choroid. This method allows precise assessment of the retinal and choroidal layers to diagnose and follow up posterior segment diseases. We are reporting normal cut-off values of macular and choroidal thicknesses in healthy Hispanic subjects evaluated with Optovue SD-OCT as new diagnostic normal parameters for research and clinical activities. Keywords: Spectral domain optical coherence tomography, Macular thickness, Choroidal thickness, Hispanic population, Normal cut-off values Introduction Since the introduction of Optical Coherence Tomography (OCT) in the 20th century, it has been possible to assess retinal and choroidal diseases more precisely. *Correspondence: [email protected] 1 Fundación Oftalmológica Nacional, Calle 50 # 13‑50, Bogotá, Bogota, Colombia Full list of author information is available at the end of the article
OCT is a non-invasive transpupillary method aimed with a laser system to obtain accurate measurements in vivo of the retina and choroid layers [1]. These devices use two different technologies for imaging, known as time domain (TD) and spectral domain (SD). Spectral Domain OCT, also known as Fourier-domain OCT, acquires images 100 times faster than TD technology, giving higher image resolution [2, 3].
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