Malatya and Other Criteria for Liver Transplantation in Hepatocellular Carcinoma
- PDF / 222,712 Bytes
- 4 Pages / 595.276 x 790.866 pts Page_size
- 94 Downloads / 222 Views
REVIEW ARTICLE
Malatya and Other Criteria for Liver Transplantation in Hepatocellular Carcinoma Volkan Ince 1
&
Cengiz Ara 1
&
Sezai Yilmaz 1
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose Liver transplantation is a curative treatment option for hepatocellular carcinoma. In this review, we aimed to review liver transplantation criteria for hepatocellular carcinoma and patient survivals. Methods We reviewed literature in terms of liver transplant criteria for hepatocellular carcinoma. Patient eligibility criteria, posttransplant survivals, tumor recurrence and expansion of Milan criteria rates were analyzed. Results The Milan criteria, after being published in 1996, have become for deceased donor liver transplantation in hepatocellular carcinoma worldwide. Later, many transplant centers published their own liver transplant criteria. Most of the criteria consisted of morphological tumor characteristics based on tumor size and number. The newest published one is Malatya criteria. The 5-year overall survival according the all of the criteria is greater than 50%. There were just one paper which compare criteria according to survival and Malatya criteria were the best amongst extended criteria with 5-year OS 79.7% in that study. Conclusion It is clear that morphological criteria consisting only of tumor size and number are insufficient in patient selection for liver transplantation and should thus be combined with biological, inflammatory, radiological, pathological and genetic markers that predict the biological behavior of the tumor. Efforts to find the best criteria are still ongoing and 5-year overall survival should be greater than 60%. Keywords Live donor . Extended criteria . Liver cancer . Expansion rate
Abbreviations AFP Alpha fetoprotein BCLC Barcelona Clinic Liver Cancer extended criteria DDLT Deceased donor liver transplantation ETC Extended Toronto criteria GGT Gamma glutamyl transferase HC Hagzhou criteria HCC Hepatocellular cancer LT Liver transplantation LDLT Live donor liver transplantation LRT Loco-regional therapy MC Milan criteria MTD Maximal tumor diameter NLR Neutrophil-lymphocyte ratio
* Volkan Ince [email protected] 1
Department of Surgery, Liver Transplantation Institute, Inonu University, 44315 Malatya, Turkey
OS PET/CT TTS UCSF
Overall survival Positron Emission Tomography / computerized tomography scan Total tumor size University of California, San Francisco criteria
Introduction Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third most common cause of cancer death worldwide [1]. Liver transplantation (LT) provides the only recurrence-free curative treatment option, and the Milan criteria (MC) are adopted worldwide to select patients with HCC for LT [2]. However, MC are based on tumor morphological features and are too strict, and thus, patients with favorable tumor biology who are beyond these criteria are excluded from LT and lose the opportunity for curative treatment [2]. Extended Milan criteria were then publ
Data Loading...
