Malignant tumours of temporomandibular joint
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RESEARCH ARTICLE
Open Access
Malignant tumours of temporomandibular joint Feiluore Yibulayin1,2†, Chen-xi Yu1,3†, Lei Feng1, Meng Wang1, Meng-meng Lu1, Yuan Luo1, Hui Liu1, Zhi-cheng Yang1* and Alimujiang Wushou1*
Abstract Background: Malignant tumours of the temporomandibular joint (MTTMJ) are extremely rare. Studies describing its unique epidemiology, clinicopathological features, treatment and prognosis comprehensively are limited. To address these issues, current investigation was performed. Methods: A retrospective research was carried out by using population-based data from the Surveillance, Epidemiology, and End Results database (1973–2016). Results: Data for a total of 734 patients, including 376 men and 358 women, was found. The median age was 47 years. The 5-year and 10-year disease specific survival (DSS) rates were 69.2 and 63.6%, respectively. Significant differences in DSS were found according to age, race, tumour type, AJCC/TNM stage, surgery, radiotherapy, chemotherapy and different treatment modalities (P < 0.05). In the multivariate survival analysis, age > 44 years and AJCC stage III and IV were associated with poor DSS. Conclusion: MTTMJ was mostly found in white people with a median age of 47 years without any sex predominance. Patient’s age and AJCC stage was independent predictor of DSS. Keywords: Temporomandibular joint, Malignant tumour, SEER analysis
Background Temporomandibular joint (TMJ) disorders are very common and can be easily diagnosed [1, 2]. However, malignant tumours of the temporomandibular joint (MTTMJ) are very rare and often cause facial asymmetry deformity and occlusal disorders [3]. MTTMJ originates from three possible sites: (a) intrinsic tissue of the TMJ, (b) extension of malignant tumours from adjacent issues, such as parotid gland malignant neoplasm, and (c) distant metastatic spread to the joint. Among these tumours, primary tumours from intrinsic tissue of the * Correspondence: [email protected]; [email protected] † Feiluore Yibulayin and Chen-xi Yu contributed equally to this work. 1 Department of Oral & Maxillofacial Surgery and Oral Biomedical Engineering Laboratory Shanghai Stomatological Hospital Fudan University, 356 Beijing East Road, Shanghai 200001, People’s Republic of China Full list of author information is available at the end of the article
TMJ are extremely rare. MTTMJ patients may present with complex signs and symptoms that mimic those of myofascial pain and dysfunction syndrome, such as TMJ disorders [4]. As a result, the clinical manifestation and differential diagnosis of TMJ malignancies is challenging for primary care doctors [5]. Early diagnosis and treatment are important in achieving good prognosis in MTTMJ patients. As it is a solid tumour, surgical resection is the most important treatment modality for MTTMJ, and chemoradiotherapy is given as adjuvant therapy for advanced stage tumours and metastatic disease [6]. Surgical reconstruction of the TMJ is difficult, and poor treatment could result in loss of function, disfigu
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