Management of Retinitis Pigmentosa via Platelet-Rich Plasma or Combination with Electromagnetic Stimulation: Retrospecti
- PDF / 3,699,015 Bytes
- 23 Pages / 595.276 x 790.866 pts Page_size
- 80 Downloads / 155 Views
ORIGINAL RESEARCH
Management of Retinitis Pigmentosa via Platelet-Rich Plasma or Combination with Electromagnetic Stimulation: Retrospective Analysis of 1-Year Results ¨ zmert Umut Arslan . Emin O
Received: February 20, 2020 Ó Springer Healthcare Ltd., part of Springer Nature 2020
ABSTRACT Purpose: To investigate whether the natural progression rate of retinitis pigmentosa can be decreased by subtenon autologous platelet-rich plasma application alone or combination with retinal electromagnetic stimulation. Methods: The study includes retrospective analysis of 60 patients with retinitis pigmentosa. Patients constitute three groups with similar demographic characteristics: the combined management group (group 1) consists of 20 patients with retinitis pigmentosa (40 eyes) who received combined retinal electromagnetic stimulation and subtenon platelet-rich plasma; the subtenon platelet-rich plasma-only group (group 2) consisted of 20 patients with retinitis pigmentosa (40 eyes); the natural course (control) group (group 3) consists of 20 patients with retinitis pigmentosa (40 eyes) who did not receive any treatment. Horizontal and vertical ellipsoid zone width, fundus perimetry Enhanced digital features To view digital features for this article go to https://doi.org/10.6084/m9.figshare. 11994795. U. Arslan (&) Ankara University Technopolis, Ankara, Turkey e-mail: [email protected]; [email protected] ¨ zmert E. O Department of Ophthalmology, Faculty of Medicine, Ankara University, Ankara, Turkey
deviation index, and best corrected visual acuity changes were compared within and between groups after a 1-year follow-up period. Results: Detected horizontal ellipsoid zone percentage changes were ? 1% in group 1, - 2.85% in group 2, and - 9.36% in group 3 (Dp 1 [ 2 [ 3). Detected vertical ellipsoid zone percentage changes were ? 0.34% in group 1, - 3.05% in group 2, and - 9.09% in group 3 (Dp 1 [ 2 [ 3). Detected fundus perimetry deviation index percentage changes were ? 0.05% in group 1, - 2.68% in group 2, and - 8.78% in group 3 (Dp 1 [ 2 [ 3). Conclusion: Platelet-rich plasma is a good source of growth factors, but its half-life is 4–6 months. Subtenon autologous platelet-rich plasma might more effectively slow down photoreceptor loss when repeated as booster injections and combined with retinal electromagnetic stimulation. Trial Registration: ClinicalTrials.gov identifier, NCT04252534. Keywords: Electromagnetic stimulation; Growth factors; Iontophoresis; Magnovision; Ophthalmology; Platelet-rich plasma; Retinitis pigmentosa
Adv Ther
Key Summary Points Why carry out this study? To investigate whether the natural progression rate of retinitis pigmentosa can be decreased by subtenon autologous platelet-rich plasma application alone or combination with retinal electromagnetic stimulation. The retina pigment epithelium is the unit center where the synthesized peptide growth factors (GFs) regulate photochemical reactions. The growth factors, peptides, and fragments required for these functions are encoded by
Data Loading...
