Maternal diabetes and risk of childhood malignancies in the offspring: a systematic review and meta-analysis of observat
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ORIGINAL ARTICLE
Maternal diabetes and risk of childhood malignancies in the offspring: a systematic review and meta‑analysis of observational studies Pengfei Yan1 · Yongbo Wang2 · Xue Yu1 · Yu Liu3 · Zhi‑Jiang Zhang1 Received: 13 July 2020 / Accepted: 20 August 2020 © Springer-Verlag Italia S.r.l., part of Springer Nature 2020
Abstract Aims Diabetes mellitus (DM) is widely recognized as a risk factor for diverse cancers in adults. However, the association between maternal diabetes and risk of childhood cancer in the offspring has so far not been well studied. We thus conducted a meta-analysis to evaluate the role of maternal diabetes on the risk of childhood cancer. Methods We performed a comprehensive literature search to identify eligible studies published up to June 20, 2020, including the PubMed, Web of science and Embase databases. Summary odds ratios (OR) and 95% confidence intervals (CI) were computed using a random-effects model (I2 ≥ 25%) or a fixed-effect model (I2
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