Risk of developing metabolic syndrome after gestational diabetes mellitus - a systematic review and meta-analysis
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REVIEW
Risk of developing metabolic syndrome after gestational diabetes mellitus ‑ a systematic review and meta‑analysis A. Tranidou1,2 · T. Dagklis1 · I. Tsakiridis1 · A. Siargkas1,2 · A. Apostolopoulou2 · A. Mamopoulos1 · D. G. Goulis3 · M. Chourdakis2,4 Received: 1 August 2020 / Accepted: 30 October 2020 © Italian Society of Endocrinology (SIE) 2020
Abstract Purpose A systematic review and meta-analysis were conducted to quantitatively synthesize the current evidence regarding the risk of developing metabolic syndrome (MetS) in women with a personal history of gestational diabetes mellitus (GDM), without pre-existing diabetes, compared with those without a history of GDM. Methods Four electronic databases [MEDLINE (via PubMed), Scopus, Cochrane Library, PROSPERO] were searched for relevant literature until July 29th 2020. Cochran’s Q test was applied for the assessment of heterogeneity. The random-effects model was applied by calculating the odds ratio (OR) and 95% confidence interval (CI) for each study. Publication bias was estimated with Egger’s linear regression test. Results The results from 23 studies (10,230 pregnant women; 5169 cases, 5061 controls), indicated that women with a history of GDM had a higher risk of developing MetS compared with those without such a history (OR 3.45; 95% CI 2.80–4.25, p
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