Measurement of Antibody Concentrations by Hemagglutination
During every stage of development and production of diagnostic or therapeutic antibodies, it is necessary to have an assay to measure antibody concentration. Several techniques are routine in virtually all antibody laboratories. High-performance liquid ch
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METHODS IN MOLECULAR MEDICINE
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John M. Walker, SERIES EDITOR Gene Therapy Protocols, edited by Paul D. Robbins, 1997 Herpes Simplex Virus Protocols, edited by Moira S. Brown and Alisdair MacLean, 1997 Helicobacter pylori Protocols, edited by Christopher L. Clayton and Harry T. Mobley, 1997 Lectins in Medical Research, edited by Jonathan M. Rhodes and Jeremy D. Milton, 1997 Human Cell Culture Protocols, edited by Gareth E. Jones, 1996 Antisense Therapeutics, edited by Sudhir Agrawal, 1996 Vaccine Protocols, edited by Andrew Robinson, Graham H. Farrar, and Christopher N. Wiblin, 1996 Prion Diseases, edited by Harry F. Baker and Rosalind M. Ridley, 1996 Molecular Diagnosis of Cancer, edited by Finbarr Cotter, 1996 Molecular Diagnosis of Genetic Diseases, edited by Rob Elles, 1996
METHODS IN MOLECULAR MEDICINE
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Diagnostic and Therapeutic Antibodies Edited by
Andrew J. T. George Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
and
Catherine E. Urch Department of Pharmacology, University College, London, UK
Humana Press
Totowa, New Jersey
© 2000 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512 All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. Methods in Molecular Medicine™ is a trademark of The Humana Press Inc. All authored papers, comments, opinions, conclusions, or recommendations are those of the author(s), and do not necessarily reflect the views of the publisher. This publication is printed on acid-free paper. ∞ ANSI Z39.48-1984 (American Standards Institute) Permanence of Paper for Printed Library Materials. The cover illustration shows a model of the entire human IgG1 molecule. It was generated using the RasMol program (1) from a composite model generated by Dr. Eduardo Padlan of the National Institutes of Health, Bethesda, MD, using coordinates for F(ab’)2 and Fc fragments and theoretical modeling of the hinge region. The model is described in Padlan (2). The PDB file is available from http://www.umass.edu/microbio/ rasmol/padlan.htm. 1. Sayle, R. A. and Milner, W.-E. J. (1995) RasMol: biomolecular graphics for all. Trends Biochem. Sci. 20, 374. 2. Padlan, E. A. (1994) Anatomy of the antibody molecule. Mol. Immunol. 31, 169–217. For additional copies, pricing for bulk purchases, and/or information about other Humana titles, contact Humana at the above address or at any of the following numbers: Tel.: 973-256-1699; Fax: 973-256-8341; E-mail: [email protected] Photocopy Authorization Policy: Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Humana Press Inc., provided that the base fee of US $10.00 per copy, plus US $00.25 per page, is paid directly to the Copyright Clearance Center at 222 Rosewood Drive, Danvers, MA 01923. For those organiz
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