Mechanical Stretch and Cytokines
This book presents the latest findings in the field of investigation of molecular mechanisms of mechanical stretch and the role of cytokines in response of different tissues to it. On the one hand this Volume demonstrates how mechanical stretch enhances c
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Mechanosensitivity in Cells and Tissues Volume 5
Series Editors A. Kamkin Department of Fundamental and Applied Physiology, Russian State Medical University, Ostrovitjanova Str. 1, 117997 Moscow, Russia I. Kiseleva Department of Fundamental and Applied Physiology, Russian State Medical University, Ostrovitjanova Str. 1, 117997 Moscow, Russia
For further volumes: http://www.springer.com/series/7878
Andre Kamkin · Irina Kiseleva Editors
Mechanical Stretch and Cytokines
Foreword by Leonid V. Rosenshtraukh
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Editors Prof. Andre Kamkin Department of Fundamental and Applied Physiology Russian State Medical University Ostrovitjanova Str. 1 117997 Moscow Russia [email protected]; [email protected]
Prof. Irina Kiseleva Department of Fundamental and Applied Physiology Russian State Medical University Ostrovitjanova Str. 1 117997 Moscow Russia
Editorial Assistant Dr. Natalia E. Lapina Division of Neurosurgical Research Medical Faculty Mannheim Ruprecht-Karls-University Heidelberg Theodor-Kutzer-Ufer 1-3 D-68167 Mannheim Germany [email protected]
ISBN 978-94-007-2003-9 e-ISBN 978-94-007-2004-6 DOI 10.1007/978-94-007-2004-6 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2011936153 © Springer Science+Business Media B.V. 2012 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
The book “Mechanosensitivity in Cells and Tissues: Mechanical Stretch and Cytokines” edited by Andre Kamkin and Irina Kiseleva impressively demonstrates the diversity of cellular effects of cytokines depending on mechanical stimuli. Clinical and fundamental investigation of biological effects of cytokines in regulation of functioning of cells, tissues and organs is a relatively new, interesting and fast growing field, which draws a lot of attention recently. A proposed link between cytokines, their production and mechanisms of action, and their impact on effects of cellular and tissue stretch given a new momentum to this field. The role of cytokines as regulators of stretch related mechanisms is of special importance since mechanosensitivity plays an important role in a wide variety of biological processes. It is known that cytokines can be marked out as a new separate regulatory system which, along with nervous and endocrine systems, helps to maintain homeostasis, and these three systems are tightly interconnected and interdependent. Presently two major approaches to investigation of cytokines and mechanosensitivity exist. The first one focuses on the effects of interplay of mechanical stimulation of tissue or cells a
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