Cytokines and Joint Injury
The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction. This is of relevance for
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Series Editor Prof. Dr. Michael J. Parnham Senior Scientific Advisor PLiVA dd Prilaz baruna Filipovica 25 10000 Zagreb Croatia
Advisory Board G. Z. Feuerstein (Merck Research Laboratories, West Point, PA, USA) M. Pairet (Boehringer Ingelheim Pharma KG, Biberach a. d. Riss, Germany) W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)
Forthcoming titles: Cancer and Inflammation, D.W. Morgan, M. Nakada, U. Forssmann (Editors), 2004 Antirheumatic Therapy: Actions and Outcomes, R.O . Day, D.E. Furst, P.L. van Riel (Editors), 2004 Antibiotics as Anti-inflammatory and Immunomodulatory Agents, B. Rubin, J. Tamaoki (Editors), 2004 (Already published titles see last page.)
Cytokines and Joint Injury
Wim B. van den Berg Pierre Miossec Editors
Springer BaseL AG
Editors Prof. Or. Wim B. van den Berg Rheumatology Research Lab University Medical Center Nijmegen, 189 Geert Grooteplein 26-28 6500 HB Nijmegen The Netherlands
Prof. Or. Pierre Miossec Universite Claude Bernard - Lyon 1 Hâpital Edouard Herriot Service de Rhumatologie Unite d'lmmunologie Clinique 69437 Lyon France
A CIP catalogue record for this book is available from the Library of Congress, Washington O.c., USA
Bibliographic information published by Oie Oeutsche Bibliothek Oie Oeutsche Bibliothek lists this publication in the Oeutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb.de
The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt Irom the relevant protective laws and regulations or free for general use.
ISBN 978-3-0348-9609-2 ISBN 978-3-0348-7883-8 (eBook) DOI 10.1007/1978-3-0348-7883-8 This work is subject to copyright. AII rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained.
© 2004 Springer Basel AG Originally published by Birkhăuser Verlag ,Basel, Swilzerland in 2004 Printed on acid-free paper produced from chlorine-free pulp. TCF
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Cover design: Markus Etlerich, Basel Cover illustration: Expression of receptor activator of nuclear factor kappaB (RANK) at sites of focal bone erosion (see p.
274). With the friendly permission of Erik Lubberls and Wim B. van den Berg. ISBN 978-3-0348-9609-2
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Contents
List of contributors
vii
Preface
xi
Ravinder N. Maini The role of tumour necrosis factor in rheumatoid arthritis
1
Charles A. Dinarello The IL-1 family: the role of IL-1 and IL-18 in inflammation
29
Cem Gabay Targeted IL-1 inhibition
69
Norihiro Nishimoto
