Mechanism of Functional Expression of the Molecular Machines
This brief discusses the mechanism of functional expression of a protein or protein complex utilizing the ATP hydrolysis cycle or proton-motive force from a unique point of view focused on the roles of water. A variety of processes are considered such as
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Masahiro Kinoshita
Mechanism of Functional Expression of the Molecular Machines 123
SpringerBriefs in Molecular Science
More information about this series at http://www.springer.com/series/8898
Masahiro Kinoshita
Mechanism of Functional Expression of the Molecular Machines
13
Masahiro Kinoshita Institute of Advanced Energy Kyoto University Kyoto Japan
ISSN 2191-5407 ISSN 2191-5415 (electronic) SpringerBriefs in Molecular Science ISBN 978-981-10-1484-0 ISBN 978-981-10-1486-4 (eBook) DOI 10.1007/978-981-10-1486-4 Library of Congress Control Number: 2016942489 © The Author(s) 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Science+Business Media Singapore Pte Ltd.
Preface
In this book, we briefly discuss the mechanism of functional expression of a protein or protein complex utilizing the ATP hydrolysis cycle or proton-motive force from a unique point of view which has not yet been adopted. We consider a variety of processes such as the unidirectional movement of a linear-motor protein along a filament, insertion of an unfolded protein into a chaperonin and release of the folded protein from it, transport of diverse substrates across the membrane by a transporter, and directed rotation of the central subunit within a rotatory-motor protein complex. It is shown that water plays imperative roles in the functional expression of these molecular machines. A pivotal factor is the entropic effect, force, or potential originating from the translational displacement of water molecules coexisting with the molecular machines in the entire system. It is pointed out that the processes mentioned above (they are referred to as “ordering processes” in this book) and the selfassembly processes such as protein folding and association can be comprehended in a unified manner within the same theoretical framework. The differences between the ordering and self-as
