Mechanobiology of Cell-Cell and Cell-Matrix Interactions
Mechanobiology of Cell-Cell and Cell-Matrix Interactions focuses on characterization and modeling of interactions between cells and their local extracellular environment, exploring how these interactions may mediate cell behavior. Studies of cell-matrix i
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. Wagoner Johnson
l
Brendan A.C. Harley
Editors
Mechanobiology of Cell‐Cell and Cell‐Matrix Interactions
Editors A. Wagoner Johnson Department of Mechanical & Industrial Engineering University of Illinois, Urbana‐Champaign 1206 W. Green St. Urbana, Illinois 61801 USA [email protected]
Brendan A.C. Harley Department of Chemical & Biomolecular Engineering University of Illinois, Urbana-Champaign 600 S. Mathews Ave. Urbana, Illinois 61801 USA [email protected]
ISBN 978-1-4419-8082-3 e-ISBN 978-1-4419-8083-0 DOI 10.1007/978-1-4419-8083-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011921261 # Springer ScienceþBusiness Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Cell behavior is modulated by a complex, spatio-temporally integrated set of biophysical mechanisms influenced by the biochemistry of extracellular and intracellular signaling, but also by the properties of the surrounding extracellular environment. A cell assimilates multiple cues from its microenvironment, including signals bound to the extracellular matrix and neighboring cells, mechanical stimuli, and soluble signals from both adjacent and distant cells. The cell then responds to these signals via multiple pathways, each involving multiple cascades of internal molecular interactions. While much as been learned over the past decade regarding the mechanobiology of how cells interact with their surrounding environment in cases of physiology and disease, many fundamental questions remain. New tools as well as experimental and modeling approaches now enable researchers to answer a host of complex questions regarding the biophysics of how cells sense and respond to each other as well as to the multitude of extrinsic signals present in their local microenvironment. Continued progress in the field requires continued, close interactions between researchers in engineering, biology, physics, and medicine, but promises significant advances in the fields of regenerative biology and tissue engineering. This peer-reviewed book is one result of the Society of Engineering Science (SES) 45th Annual Technical Meeting, held October 12–15, 2008 at the University of Illinois at Urbana-Champaign. The meeting brought together scientists, en
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