Molecular and Cellular Mechanobiology

This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcri

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Shu Chien Adam J. Engler Peter Yingxiao Wang Editors

Molecular and Cellular Mechanobiology

Physiology in Health and Disease

Published on behalf of The American Physiological Society by Springer

Physiology in Health and Disease This book series is published on behalf of the American Physiological Society (APS) by Springer. Access to APS books published with Springer is free to APS members. APS publishes three book series in partnership with Springer: Physiology in Health and Disease (formerly Clinical Physiology), Methods in Physiology, and Perspectives in Physiology (formerly People and Ideas), as well as general titles. More information about this series at http://www.springer.com/series/11780

Shu Chien • Adam J. Engler Peter Yingxiao Wang Editors

Molecular and Cellular Mechanobiology

Editors Shu Chien Professor of Bioengineering and Medicine University of California, San Diego La Jolla, CA, USA

Adam J. Engler Associate Professor of Bioengineering University of California, San Diego La Jolla, CA, USA

Peter Yingxiao Wang Associate Professor of Bioengineering University of California, San Diego La Jolla, CA, USA

Physiology in Health and Disease ISBN 978-1-4939-5615-9 ISBN 978-1-4939-5617-3 DOI 10.1007/978-1-4939-5617-3

(eBook)

Library of Congress Control Number: 2016945272 © The American Physiological Society 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York

Preface

At the request of the American Physiological Society, we have edited this book on Molecular and Cellular Mechanobiology as part of the “Perspectives in Physiology” series. Mechanobiology is a rapidly developing scientific field at the interface of biology, medicine, and engineering that studies how physical forces, cell/tissue mechanics, and their interactions regulate homeostasis in health and pathophysiological changes in disease. Mechanobiology