Mediation model of comorbid anxiety disorders in late-life depression
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Annals of General Psychiatry Open Access
PRIMARY RESEARCH
Mediation model of comorbid anxiety disorders in late‑life depression Chawisa Suradom1, Nahathai Wongpakaran1* , Tinakon Wongpakaran1, Peerasak Lerttrakarnnon2, Surin Jiraniramai2, Unchulee Taemeeyapradit3, Surang Lertkachatarn4, Suwanna Arunpongpaisal5 and Pimolpun Kuntawong1
Abstract Background: A number of studies have been conducted on risk factors of comorbid anxiety disorders regarding late-life depression (LLD). This study investigated the associated factors and their relationship to comorbid anxiety disorders in LLD. Methods: Participants included 190 elderly Thais (73.2% female, with a mean age of 68.39 ± 6.74 years) with depressive disorders, diagnosed according to DSM-IV Diagnosis Axis I disorders assessed by Mini-International Neuropsychiatric Interview. Demographic data, medical and psychiatric history, family psychiatric history, past depression, family history of depression, Neuroticism Inventory and 7-Item Hamilton Depression Rating Scale (HAMD-7) were analyzed for path analysis using Structural Equation Model framework. The bootstrapping method was used for testing indirect effects. Results: Being female was associated with comorbid anxiety disorders with an indirect effect (β = − 0.032, P = 0.018) through neuroticism, depression severity, history and family history of depression. Family history of depression had no effect on comorbidity (P = 0.090). Neuroticism had an indirect effect on comorbid anxiety disorders (β = 0.075, P = 0.019) via depression severity as reflected by HAMD-7 score (β = 0.412, P = 0.05, CFI and TLI > 0.95 and RMSEA 0.95 and root mean square error of approximation (RMSEA)
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