Medicinal Organometallic Chemistry

Contents: Gérard Jaouen, Nils Metzler-Nolte : Introduction ; Stéphane GIBAUD and Gérard JAOUEN: Arsenic - based drugs: from Fowler’s solution to modern anticancer chemotherapy; Ana M. Pizarro, Abraha Habtemariam and Peter J. Sadler : Activation Mechanisms

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Editorial Board: M. Beller J. M. Brown P. H. Dixneuf A. Fu¨rstner L. S. Hegedus P. Hofmann T. Ikariya L. A. Oro M. Reetz Q.-L. Zhou l

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Medicinal Organometallic Chemistry

Volume Editors: Ge´rard Jaouen and Nils Metzler-Nolte

With Contributions by Roger Alberto  Christophe Biot  Angela Casini  Daniel Dive  Paul J. Dyson  Ste´phane Gibaud  Abraha Habtemariam  Christian G. Hartinger  Elizabeth A. Hillard  Megan Hogan  Ge´rard Jaouen  Brian E. Mann  Eric Meggers  Seann P. Mulcahy  Alexey A. Nazarov  Nils Metzler-Nolte  Ana M. Pizarro  Peter J. Sadler  Matthias Tacke  Anne Vessie`res

Editors Prof. Ge´rard Jaouen CNRS Laboratoire de Chimie et Biochimie des complexes moleculaires Ecole Nationale Superieure de Chimie de Paris 11 rue Pierre et Marie Curie 75231 Paris France [email protected] Prof. Dr. Nils Metzler-Nolte Lehrstuhl fu¨r Anorganische Chemie 1 Bioanorganische Chemie Ruhr-Universita¨t Bochum Universita¨tsstr. 150 44801 Bochum Germany [email protected]

ISSN 1436-6002 e-ISSN 1616-8534 ISBN 978-3-642-13184-4 e-ISBN 978-3-642-13185-1 DOI 10.1007/978-3-642-13185-1 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2010936349