Synthesis of Heterocycles in Contemporary Medicinal Chemistry
The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and
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enko Časar Editor
Synthesis of Heterocycles in Contemporary Medicinal Chemistry
44 Topics in Heterocyclic Chemistry
Series Editors: Bert Maes, Antwerp, Belgium Janine Cossy, Paris, France Slovenko Polanc, Ljubljana, Slovenia
Editorial Board: D. Enders, Aachen, Germany S.V. Ley, Cambridge, UK G. Mehta, Bangalore, India R. Noyori, Hirosawa, Japan L.E. Overmann, Irvine, CA, USA A. Padwa, Atlanta, GA, USA
Aims and Scope The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field.
More information about this series at http://www.springer.com/series/7081
Zdenko Cˇasar Editor
Synthesis of Heterocycles in Contemporary Medicinal Chemistry With contributions by R. Barth A. Bauer Z. Cˇasar F. Gallou S. Lemaire S. Nerdinger F. Richter C.A. Rose D. Schils O. Scho¨ne E. Schreiner Y.S. Tsantrizos
Editor ˇ asar Zdenko C Sandoz Development Center Slovenia, Lek Pharmaceuticals d.d. Ljubljana Slovenia Global Portfolio Management, Sandoz GmbH Kundl Austria Faculty of Pharmacy University of Ljubljana Ljubljana Slovenia
ISSN 1861-9282 ISSN 1861-9290 (electronic) Topics in Heterocyclic Chemistry ISBN 978-3-319-39915-7 ISBN 978-3-319-39917-1 (eBook) DOI 10.1007/978-3-319-39917-1 Library of Congress Control Number: 2016944466 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
Heterocyclic compounds have had a central role in medicinal chemistry, and they have made notable con
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