Melatonin ingestion before intradialytic exercise improves immune responses in hemodialysis patients
- PDF / 772,827 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 62 Downloads / 164 Views
NEPHROLOGY - ORIGINAL PAPER
Melatonin ingestion before intradialytic exercise improves immune responses in hemodialysis patients Houssem Marzougui1,2 · Omar Hammouda1,3 · Imen Ben Dhia2,4 · Rami Maaloul1,2 · Ikram Agrebi5,6 · Hanen Chaker5,6 · Khaoula Kammoun5,6 · Mohamed Ben Hmida5,6 · Fatma Ayadi1,7 · Choumous Kallel8 · Tarak Driss3 · Mouna Turki1,7 · Hatem Masmoudi9,10 · Hend Hachicha9,10 Received: 2 May 2020 / Accepted: 7 September 2020 © Springer Nature B.V. 2020
Abstract Purpose The present study aimed to investigate the effects of melatonin (MEL) intake on systemic inflammation and immune responses during intradialytic exercise. Methods Thirteen hemodialysis (HD) patients volunteered to participate in the current randomized-crossover study. Immunological responses were monitored in four HD sessions at different conditions: [Exercise (EX) + MEL], [EX + Placebo (PLA)], [Control (CON) + MEL] and [CON + PLA]. MEL (3 mg) or PLA was ingested 1 h before starting exercise or the equivalent time in CON condition. During all sessions, peripheral blood samples were collected to assess c-reactive protein, complete blood count, and immune cells phenotypes before HD (T0), immediately after exercise (T1) and 1 h after exercise (T2) or at corresponding times in the CON condition. Results HD therapy induced a significant decrease in natural killer (NK) (p = 0.001, d = 0.85; p
Data Loading...
