Membrane Receptors, Channels and Transporters in Pulmonary Circulation
Membrane Receptors, Channels and Transporters in Pulmonary Circulation is a proceeding of the 2008 Grover Conference (Lost Valley Ranch and Conference Center, Sedalia, Colorado; September 3-7, 2008), which provided a forum for experts in the fields of tho
- PDF / 11,616,029 Bytes
- 498 Pages / 439.37 x 666.142 pts Page_size
- 94 Downloads / 166 Views
For other titles published in this series, go to www.springer.com/series/5584
Jason X.-J. Yuan Jeremy P.T. Ward ●
Editors
Membrane Receptors, Channels and Transporters in Pulmonary Circulation
Editors J.X.-J.Yuan University of California, San Diego Department of Medicine 9500 Gilman Drive La Jolla, CA 92093 USA [email protected]
J.P.T. Ward King’s College London Guy’s Hospital Campus Department of Physiology London United Kingdom SE1 1UL [email protected]
ISBN 978-1-60761-499-9 e-ISBN 978-1-60761-500-2 DOI 10.1007/978-1-60761-500-2 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2009933121 © Humana Press, a part of Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Receptors, channels, and transporters play a critical role in vascular signal transduction and are key elements in the pathogenesis of pulmonary vascular disease. They provide front-line mechanisms for regulation of normal smooth muscle, for endothelial and inflammatory cellular homeostasis, and for responding to the extracellular environment and external mediators. Pathophysiological perturbations in their function and expression are associated with profound alterations in cellular function and make significant contributions to the development and progression of disease. As they are in the main situated in the plasma membrane and their molecular nature is often conducive to modulation of function by relatively highly specific agents, receptors, channels, and transporters are potentially key targets for novel therapeutics. Indeed, a high proportion of currently available therapeutic agents function as channel or transporter modulators or receptor antagonists and agonists. Over the last few years, there have been significant advances in our understanding concerning the expression and function of novel channels, receptors, and transporters in the pulmonary circulation. Since the last Grover conference on the role of ion flux in pulmonary vascular control in 1992, several entirely new molecular classes of ion channels (e.g., transient receptor potential [TRP] channels and two-pore domain K+ channels) have been identified and have more recently been shown to play key roles in pulmona
Data Loading...
