Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters
Knowledge of cardiac ion channels and transporters has advanced remarkably in the last two decades with the development of patch-clamp and molecular biological techniques. This textbook offers a comprehensive overview of structures and functions of ion ch
- PDF / 79,874,730 Bytes
- 586 Pages / 553 x 737 pts Page_size
- 111 Downloads / 190 Views
Developments in Cardiovascular Medicine VOLUME 182
The titles published in this series are listed at the end of this volume.
MOLECULAR PHYSIOLOGY AND PHARMACOLOGY OF CARDIAC ION CHANNELS AND TRANSPORTERS Edited by
M.MORAD Georgetown University Medical Center Washington, DC, U.S.A.
S. EBASHI National Institute for Physiological Sciences Okazaki, Japan
W. TRAUTWEIN Universităt des Saarlandes Homburg/Saar, Germany
and
Y. KURACHI Department of Pharmacology II, Faculty of Medicine Osaka University, Suita, Japan
Springer Science+Business Media, B.V.
Library of Congress Cataloging-in-Publication Data
Molecular physiology and pharmacology of cardiac ion channels and transporters I edited by M. Morad ... [et al.l. p. cm. -- (Developments in cardlovascular medicine v. 1821 Includes Index. ISBN 978-94-010-5765-3 ISBN 978-94-011-3990-8 (eBook) DOI 10.1007/978-94-011-3990-8
1. Heart--Physiology. 2. Heart--Pathophysiology. channels. I. Morad, Martin. II. Series. QP"'.4.M65 1996 612.1'7--dc20
3. Ion 95-51375
ISBN 978-94-010-5765-3
Printed on acid-free paper
Cover illustrations: Electrophysiological tracings (Pfluger Arch 1982; 393: 15-22); Photomicrograph of SA nodal cells (PflUger Arch 1984; 402: 248-57). Reproduced with permission.
AII Rights Reserved Springer Science+Business Media Dordrecht Originally published by Kluwer Academic Publishers in 1996 Softcover reprint of the hardcover 1st edition 1996 No part of the material protected by this copyright notice may be reproduced or utilized in any form or by any means. electronic or mechanical. inc1uding photocopying. recording or by any information storage and retrieval system, without written permission from the copyright owner.
© 1996
Table of contents
List of Contributors Preface Thoughts of my friend, Hiroshi Irisawa Setsuro Ebashi Dr Hiroshi Irisawa during his youth and physiology Issei Seyama PART ONE Section I: Channels and channel proteins Chapter 1: Introduction 1. Overview: channels and channel proteins H. Criss Hartzell
IX
xiii xv xix
1 3
Chapter 2: A pacemaker channel 2. The hyperpolarization-activated inward channel and cardiac pacemaker activity Hillary F. Brown and Won-Kyung Ho 3. The hyperpolarization-activated (If) current: autonomic regulation and the control of pacing Dario DiFrancesco Chapter 3: The cardiac Na+ channel 4. Current understanding of the structure of the voltage gated sodium channel Samuel C. Dudley, Jr. and Harry A. Fozzard 5. f3-adrenergic regulation of cardiac Na + channel Makoto Arita, Hikaru Maramatsu, Katsushige Ono and Tatsuto Kiyosue Chapter 4: The L-type cardiac Ca 2 + channel 6. L-type calcium channel structure and function Franz Hofmann and Martin Biel 7. L-type Ca channel biophysics Timothy J. Kamp and Eduardo Marban 8. f3-adrenergic and muscarinic regulation of L-type calcium current Wolfgang Trautwein and Josef Utz 9. Regulation of cardiac Ca2 + channels by cGMP and NO Rodolphe Fischmeister and Pierre-Fran90is Mery Chapter 5: The cardiac K+ channels 10. Diversity of voltage-dependent K channels Olaf Pongs
