Membrane Transport Mechanism 3D Structure and Beyond

This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing number of atomic structures of transporters in different conformations and the constant progress in bioinformatics h

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Reinhard Krämer Christine Ziegler Editors

Membrane Transport Mechanism 3D Structure and Beyond

Springer Series in Biophysics 17 Series editor: Boris Martinac

For further volumes: http://www.springer.com/series/835

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Reinhard Kra¨mer • Christine Ziegler Editors

Membrane Transport Mechanism 3D Structure and Beyond

Editors Reinhard Kra¨mer Department Chemistry Institute of Biochemistry University of Cologne Ko¨ln Germany

Christine Ziegler Faculty for Biology and Preclinical Medicine University of Regensburg Regensburg Germany

Series editor: Boris Martinac University of New South Wales Victor Chang Cardiac Research Inst. Darlinghurst New South Wales Australia

ISSN 0932-2353 ISSN 1868-2561 (electronic) ISBN 978-3-642-53838-4 ISBN 978-3-642-53839-1 (eBook) DOI 10.1007/978-3-642-53839-1 Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2014934437 © Springer-Verlag Berlin Heidelberg 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

This book is dedicated to Amy Davidson for her great devotion and contribution to the field of membrane transport; her competence and kindness will always be remembered.

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Preface

The alternating-access mechanism is a fundamental and intuitively convincing concept for the translocation of a