Memory Lymphocyte Clusters in Genital Immunity: Role of Tissue-Resident Memory T Cells (TRM)
Development of front-line defenses in genital tissues is important to inhibit viral/bacterial replication and to eliminate sexually transmitted diseases. In this chapter, we discuss the cellular composition, location, and function of memory lymphocyte clu
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Introduction.......................................................................................................................... Tertiary Lymphoid Structures and Memory Lymphocyte Cluster-like Structures............. Protective Immunity in Genital Mucosa ............................................................................. Generation and Function of TRM in Peripheral Tissues ..................................................... 4.1 The Role of CD8+ TRM in Barrier Tissues................................................................ 4.2 The Role of CD4+ TRM in Peripheral Tissues........................................................... 5 Generation and Maintenance of MLC in Genital Tissues.................................................. 5.1 MLC Formation Following HSV-2 Infection ............................................................ 5.2 MLC Formation Following Chlamydia Infection...................................................... 6 Functional Features of MLC Against Sexually Transmitted Pathogens ............................ 7 Summary and Outlook ........................................................................................................ References ..................................................................................................................................
Abstract Development of front-line defenses in genital tissues is important to inhibit viral/bacterial replication and to eliminate sexually transmitted diseases. In this chapter, we discuss the cellular composition, location, and function of memory lymphocyte clusters deployed in mucosal tissues and compare them with those in secondary lymphoid organs and tertiary lymphoid structures. Abbreviations Ab APC BALT
Antibodies Antigen-presenting cells Bronchus-associated lymphoid tissues
N. Iijima (&) National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito Asagi, Ibaraki City, Osaka 567-0085, Japan e-mail: [email protected] Current Topics in Microbiology and Immunology https://doi.org/10.1007/82_2020_213 © Springer Nature Switzerland AG 2020
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Blimp1 CLA DC DLN FABP FcRn FDC FRT HBV HEV HPV HSV ICAM-1 IFITM3 Ig KLF LA LC LN LT LTbR LTi LTo MAdCAM-1 MLC NK pIgR RANK PNAd S1PR1 SLO STD TCM TCR TD TE TEM TF TGF-b Th TK TLS TM TNF
N. Iijima
B lymphocyte-induced maturation protein-1 Cutaneous lymphocyte-associated antigen Dendritic cells Draining lymph nodes Fatty-acid-binding proteins Neonatal Fc receptor Follicular dendritic cells Female reproductive tract Human hepatitis B virus High endothelial venules Human papilloma virus Herpes simplex virus Intercellular adhesion molecule-1 Interferon-induced transmembrane protein 3 Immunoglobulin Kruppel-like factors Lactic acid Langerhans cells Lymph nodes Lymphotoxin LT b receptor Lymphoid tissue inducer cells Lymphoid tissue organizer cells Mucosal addressin cell adhesion molecule-1 Memory lymphocyte clusters Natural killer Polymeric Ig receptor Receptor activator of nuclear factor jB Peripheral node address
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