Mesenchymal Stem Cells in Wound Repair, Tissue Homeostasis, and Aging
Wound healing and scar remodeling are complex, multicellular processes that involve coordinated regulation of many cell types and various cytokines. The repair capacity gradually decreases with aging, constituting a severe health problem that frequently a
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Cell Aging: Mechanisms, Consequences, Rejuvenation
Stem Cell Aging: Mechanisms, Consequences, Rejuvenation
Hartmut Geiger • Heinrich Jasper Maria Carolina Florian Editors
Stem Cell Aging: Mechanisms, Consequences, Rejuvenation
Editors Hartmut Geiger Dermatology and Allergic Diseases Ulm University Ulm Germany
Maria Carolina Florian Dermatology and Allergic Diseases Ulm University Ulm Germany
Heinrich Jasper Department of Biology University of Rochester Rochester, NY USA
ISBN 978-3-7091-1231-1 ISBN 978-3-7091-1232-8 DOI 10.1007/978-3-7091-1232-8
(eBook)
Library of Congress Control Number: 2015945166 Springer Vienna Heidelberg New York Dordrecht London © Springer-Verlag Wien 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer-Verlag GmbH Wien is part of Springer Science+Business Media (www.springer.com)
Preface
In societies all around the globe, the population is aging. This fact will pose important challenges to healthcare and social systems in industrialized and emerging economies alike. It is therefore critical to devise strategies to extend the healthy years of life and thus limit the exponential increase in healthcare cost associated with growing old and frail. Understanding the aging process at a fundamental level will help do so, extending healthspan and maybe even increasing lifespan. Stem cells are critical for maintaining tissue homeostasis, and age-related dysfunction of stem cells is likely the underlying cause of degeneration, regenerative dysfunction, and aging-associated disease in a great variety of organisms and tissues. Knowledge on the molecular mechanisms driving stem cell aging is thus expected to inspire rational interventions for a range of age-related pathologies. This book summarizes our current understanding of cellular and molecular mechanisms of stem cell aging in a great variety of model systems while highlighting promising approaches to attenuate stem cell aging. We hope that this book will serve
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