Mesoporous Nanofibers Mediated Targeted Anti-cancer Drug Delivery
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MRS Advances © 2018 Materials Research Society DOI: 10.1557/adv.2018.425
Mesoporous Nanofibers Mediated Targeted Anti-cancer Drug Delivery Dalong Li,1# Yilin Chen,2# Zhongyang Zhang1 and Menglin Chen1,2* 1
Interdisiplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus C, Denmark
2
Department of Engineering, Aarhus University, DK-8000 Aarhus C, Denmark
#
D. Li and Y. Chen contributed equally to the work
* Correspondence: [email protected]
ABSTRACT
Tumor tissue has different acidity compared to normal tissue. Localized drug delivery that release chemotherapeutic medications upon stimulation via pH changes is a promising strategy in cancer therapy for adjuvant therapies after surgical resection to reduce the risk of local recurrence. In this study, a mesoporous nanofibrous system with acidic pH-triggered “caps” has been for the first time developed for localized on-demand drug release to target tumor cells, without biological damage to normal cells while maintaining their structural integrity to support future tissue regeneration. Specifically, polyacrylic acid (PAA) was grafted on electrospun mesoporous silica nanofibers (MSFs) and the obtained PAA-MSFs allowed efficient drug loading at neural pH and on-demand releasing at acidic cancer subcellular compartments, based on pH-dependent electrostatic interactions associated with protonation/deprotonation of PAA. The The hybrid mesoporous nanofibers a low cytotoxicity to normal cells and a high killing efficiency to cancer cells. The system demonstrated a great potential as tumor targeting drug delivery system.
INTRODUCTION In recent years, malignant tumors have become a leading cause of death worldwide. The primary tumor treatment methods include surgical, chemotherapeutic, and radiation approaches [1-3]. Local cancer recurrence after surgical treatment occurs for most cancers, which is usually caused by inadequate resection or implantation during surgery [4-6]. Both radiation and chemotherapy are commonly used for adjuvant therapies after surgical resection to reduce the risk of local recurrence, but these therapies frequently result in severe side effects, such as initial burst release or low targeting specificity, leading to a biological damage to normal cells.
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As compared to conventional drug formulations, localized drug delivery systems offer the possibility of sustained and targeted delivery of drugs, and hence allow for improved efficacy of chemotherapy, reduced toxic side effects and decreased frequency of drug administration [7]. Thus, it is desirable to develop an implantable local drug delivery scaffold to prevent cancer recurrence by control release anticancer drugs to target tumor. Electrospinning, as a simple and versatile method for manufacturing continuous nanofibers, has been used in a broad range of appli
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