Mesoporous silica and polymer hybrid nanogels for multistage delivery of an anticancer drug
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Mesoporous silica and polymer hybrid nanogels for multistage delivery of an anticancer drug Yuan Zhan1, Haiping Wang2, Mingji Su1, Zhengguang Sun1, Yuhong Zhang1,*, and Peixin He1,2,* 1
Key Laboratory for the Green Preparation and Application of Functional Materials, Ministry of Education, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, People’s Republic of China 2 Key Laboratory of Optoelectronic Chemical Materials and Devices, Ministry of Education, Jianghan University, Wuhan 430056, China
Received: 28 July 2020
ABSTRACT
Accepted: 13 November 2020
Effective treatment of cancer has always been a major medical problem. Although some nanoformulations can guide chemotherapeutic drugs to reach the tumor sites, their large size (* 100 nm) is still the bottleneck for the treatment of solid tumors through deep penetration. In this study, we develop a kind of biodegradable hybrid nanogels to multistage delivery of anticancer drug. The nanogels can effectively encapsulate an anticancer drug (doxorubicin hydrochloride) and accelerate its release under redox and acidic conditions mimicking tumor and intracellular situations as well as controlling its release using a remote heating approach. Furthermore, the nanogels can enter the narrow space between the cells by diminishing their sizes to 40–60 nm drugcarrying mesoporous silica nanoparticles at solid tumor area, eventually entering the tumor cells and functioning in the nucleus. The drug-loaded nanogels present higher intracellular drug accumulation capacity, resulting in a two-fold enhancement in anticancer cytotoxicity as compared to free drug, suggesting their high potential as a good nanoplatform for delivery of therapeutic agents.
Published online: 25 November 2020
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Springer Science+Business
Media, LLC, part of Springer Nature 2020
Introduction Cancer is currently the leading medical problem that is characterized by proliferated indefinitely and migrated easily to normal tissues [1]. The accumulation of excessive metabolites causes the biological
microenvironment in cancerous tissues to be different from normal tissues, for example, anoxic, slightly acidic and reducing environment [2, 3]. According to those characteristics, multisensitive drug delivery systems (DDS) have widely developed to accelerate drug release in diseased tissue and greatly enhance
Handling Editor: Annela M. Seddon.
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https://doi.org/10.1007/s10853-020-05576-5
4831
J Mater Sci (2021) 56:4830–4842
the anticancer activity [4, 5]. However, complex physiological environment, including long-term blood circulation, tumor tissue penetration and cellular internalization, is a hindrance for drug-loaded nanocarriers to target tumor cells [6, 7]. Mesoporous silica nanoparticles (MSN) regarded as one of the most promising DDS, have attracted extensive concerns due to their stable mesoporous structure [8], tunable pore size and volume [9], easy fun
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