Mesothelioma From Research to Clinical Practice
This book offers an updated review of malignant mesothelioma, including the latest advances in our understanding of its genetic control and molecular biology, as well as pre-clinical and clinical research. It also presents state-of-the-art diagnostic appr
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Mesothelioma
Giovanni Luca Ceresoli Emilio Bombardieri • Maurizio D’Incalci Editors
Mesothelioma From Research to Clinical Practice
Editors Giovanni Luca Ceresoli Department of Medical Oncology Humanitas Gavazzeni Hospital Bergamo Italy
Emilio Bombardieri Scientific Direction Humanitas Gavazzeni Hospital Bergamo Italy
Maurizio D'Incalci Department of Oncology Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milano Italy
ISBN 978-3-030-16883-4 ISBN 978-3-030-16884-1 (eBook) https://doi.org/10.1007/978-3-030-16884-1 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Foreword
This book is a comprehensive—and therefore welcome—text dealing with one of the most malignant tumors, mesothelioma, fortunately relatively rare. The cause of this tumor, as stated by the International Agency for Research on Cancer (IARC), is asbestos, a generic name for a family of magnesium or other minerals and fibrous silicate minerals. In fact asbestos, which is made up of fibers, can be divided into serpentine and amphibole structures. Chrysotile is a serpentine type of asbestos with magnesium as the main element, while the group of amphiboles includes crocidolite, amosite, anthophyllite, tremolite, and actinolite. In addition to magnesium, the components may also include calcium, iron, and/or sodium. There are other fibers besides asbestos that can induce mesotheliomas, such as erionite belonging to the zeolite family, found in three villages in southeast Turkey. Some studies suggest that predisposition to the development of erionite mesothelioma is genetically transmitted as an autosomal dominant characteristic. The possible relation between cosmetic talc
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