Bacteriophage Therapy From Lab to Clinical Practice
This volume details the experimental approaches suitable for isolating and characterizing bacteriophages to formulating bacteriophage medicinal products and clinical application. Chapters guide readers through regulatory compliance and safety aspects of b
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Joana Azeredo Sanna Sillankorva Editors
Bacteriophage Therapy From Lab to Clinical Practice
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Bacteriophage Therapy From Lab to Clinical Practice
Edited by
Joana Azeredo LIBRO-Laboratory of Research in Biofilms Rosário Oliveira, CEB – Centre of Biological Engineering, University of Minho, Braga, Portugal
Sanna Sillankorva CEB – Centre of Biological Engineering, University of Minho, Braga, Portugal
Editors Joana Azeredo LIBRO-Laboratory of Research in Biofilms Rosa´rio Oliveira CEB – Centre of Biological Engineering University of Minho Braga, Portugal
Sanna Sillankorva CEB – Centre of Biological Engineering University of Minho Braga, Portugal
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7394-1 ISBN 978-1-4939-7395-8 (eBook) DOI 10.1007/978-1-4939-7395-8 Library of Congress Control Number: 2017956899 © Springer Science+Business Media LLC 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media, LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface This year we are celebrating the 100th anniversary of bacteriophage discovery. Bacteriophage therapy has had glorious and unfortunate periods. Since 1917, bacteriophages were extensively and intensively used as antimicrobial agents to control bacterial infections. In the early part of the century many big pharmaceutical companies produced several bacteriophage products for different applications. The discovery of antibiotics allied to the indiscriminate use of bacteriophages
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