Metabolic Adaptation to Extrauterine Life The antenatal role of carb

th th st . On December 19 ,20 and 21 1979, we had the opportunlty to organize a Workshop on "Antenatal factors affecting meta­ bolic adaptation to extrauterine life - Role of carbohydra­ tes and energy metabolism". This meeting was made possible thanks to

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DEVELOPMENTS IN PERINATAL MEDICINE

VOLUME 1

METABOLIC ADAPTATION TO EXTRAUTERINE LIFE The antenatal role of carbohydrates and energy metabolism Proceedings of a Workshop held in Brussels, December 19-21, 1979. Sponsored by the Commission of the European Communities, as advised by the Committee on Medical and Public Health Research.

RDEMEYER (editor)

• 1981

MARTINUS NUHOFF PUBliSHERS THE HAGUE / BOSTON / LONDON for

THE COMMISSION OF THE EUROPEAN COMMUNITIES

Distributors: for the United States and Canada Kluwer Boston, Inc. 190, Old Derby Street Hingham, MA 02043 USA for all other countries Kluwer Academic Publishers Group Distribution Center P.O. Box 322 3300 AH Dordrecht The Netherlands

This volume is listed in the Library of Congress Cataloging in Publication Data

ISBN 978-94-011-7516-6 DOl 10.1007/978-94-011-7514-2

ISBN 978-94-011-7514-2 (eBook)

Publication arranged by : Commission of the European Communities, Directorate-General Information Market and Innovation, Luxembourg EUR 6858

Copyright © ECSC, EEC, EAEC, Brussels-Luxembourg, 1981 Softcover reprint of the hardcover 1st edition 1981 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher, Martinus Nijhoff Publishers bv. P.O. Box 566,2501 CN The Hague, The Netherlands. LEGAL NOTICE Neither the Commission of the European Communities nor any person acting on behalf of the Commission is responsible for the use which might be made of the following information.

v

CONTENTS PREFACE

IX

LIST OF PARTICIPANTS

SESSION I

XVII

CARBOHYDRATE UTILIZATION IN THE NEWBORN The metabolism of glycogen in the liver of foetal and new-born rats. Hers, HG. Hormonal control of fetal liver glycogen metabolism Moses, SW, Pines, M, Bashan, N.

3

9

Extrahepatic glycogen stores and their role in homeostasis. De Meyer, R.

27

Factors regulating blood glucose in the fetus and in the newborn. Jones, CT, Rolph, T, Band, G, Michael, E.

55

Glucose turnover in the newborn rat. Snell, K.

81

Factors affecting intra uterine glycogen storage. Roux, JM.

109

Factors affecting glucose metabolism in the newborn rat. Ferre, P, Pegorier, JP, Callikan, S, Leturque, A, Girard, J.

133

Carbohydrate metabolism in intrauterine growth retardation. Kollee, LLA, Monnens, LAH, Trijbels, JMF, Veerkamp, JH.

145

Discussion: Britton, Jones, Minkowski, Hull, Milner

163

VI SESSION

II

SESSION III:

SESSION

IV:

ENERGY EXPENDITURE

165

Caloric needs of the newborn. Verellen, G.

167

Variations in the rate of oxygen consumption of newborn human infants. Hull, D.

179

Energy requirements for growth in the neonate. Sauer, PJJ, Dane, HJ, Pearse, RG, Visser, HKA.

191

The role of oleic acid as a substitute for glucose in brain cell cultures of neonatal mice. Bossi, E, Siegrist, HP.

209

Discussion: Britton, Hull, Girard, Bossi, Helge, Verellen, Minkowski.

223

REGULATION OF INSULIN AND GLUCAGON