Metabolic Interaction in Infection
This book focuses on host–pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mech
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Ricardo Silvestre · Egídio Torrado Editors
Metabolic Interaction in Infection
Experientia Supplementum
Volume 109
More information about this series at http://www.springer.com/series/4822
Ricardo Silvestre • Egídio Torrado Editors
Metabolic Interaction in Infection
Editors Ricardo Silvestre Life and Health Sciences Research Institute University of Minho Braga, Portugal
Egídio Torrado Life and Health Sciences Research Institute University of Minho Braga, Portugal
ISSN 1664-431X ISSN 2504-3692 (electronic) Experientia Supplementum ISBN 978-3-319-74931-0 ISBN 978-3-319-74932-7 (eBook) https://doi.org/10.1007/978-3-319-74932-7 Library of Congress Control Number: 2018930339 © Springer International Publishing AG, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer International Publishing AG part of Springer Nature. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
We are experiencing a renewed interest in cellular metabolism. Indeed, metabolism is now recognized to control multiple functions during cell development, differentiation, and effector function, thus playing a central role in homeostasis and disease development mechanisms. This revival has been compelled by impressive technical advances in our ability to measure metabolic processes in vitro and in vivo and to integrate distinct “omics” technologies to understand the multiple levels of metabolic regulation. The resurgence of cellular metabolism is particularly important when addressing microbial pathogenesis as it provides a new perspective on host– pathogen interactions. For too long, microbial pathogenesis and metabolism have been studied as separate entities. However, most metabolites used by pathogens and their hosts are chemically ide
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