Metabolic syndrome and myocardium steatosis in subclinical type 2 diabetes mellitus: a 1 H-magnetic resonance spectrosco
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ORIGINAL INVESTIGATION
Cardiovascular Diabetology Open Access
Metabolic syndrome and myocardium steatosis in subclinical type 2 diabetes mellitus: a 1H‑magnetic resonance spectroscopy study Yue Gao1,2†, Yan Ren3†, Ying‑kun Guo2†, Xi Liu1, Lin‑jun Xie2, Li Jiang1, Meng‑ting Shen1, Ming‑yan Deng3 and Zhi‑gang Yang1*
Abstract Background: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that collectively cause an increased risk of type 2 diabetes mellitus (T2DM) and nonatherosclerotic cardiovascular disease. This study aimed to evaluate the role of myocardial steatosis in T2DM patients with or without MetS, as well as the relationship between subclinical left ventricular (LV) myocardial dysfunction and myocardial steatosis. Methods and materials: We recruited 53 T2DM patients and 20 healthy controls underwent cardiac magnetic resonance examination. All T2DM patients were subdivide into two group: MetS group and non-MetS. LV deforma‑ tion, perfusion parameters and myocardial triglyceride (TG) content were measured and compared among these three groups. Pearson’s and Spearman analysis were performed to investigate the correlation between LV cardiac parameters and myocardial steatosis. The receiver operating characteristic curve (ROC) was performed to illustrate the relationship between myocardial steatosis and LV subclinical myocardial dysfunction. Results: An increase in myocardial TG content was found in the MetS group compared with that in the other groups (MetS vs. non-MetS: 1.54 ± 0.63% vs. 1.16 ± 0.45%; MetS vs. normal: 1.54 ± 0.63% vs. 0.61 ± 0.22%; all p
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