Metals in the Brain Measurement and Imaging
This volume explores methods used to examine metal levels and distribution in brain tissue or brain-derived cells. The chapters in this book discuss the use of fluorescent metal probes, synchrotron-based X-ray microscopy, ICP-MS, laser ablation-ICP-MS, la
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Anthony R. White Editor
Metals in the Brain Measurement and Imaging
Neuromethods
Series Editor Wolfgang Walz University of Saskatchewan Saskatoon, SK, Canada
For further volumes: http://www.springer.com/series/7657
Metals in the Brain Measurement and Imaging Edited by
Anthony R. White Department of Pathology, University of Melbourne, Melbourne, VIC, Australia
Editor Anthony R. White Department of Pathology University of Melbourne Melbourne, VIC, Australia
ISSN 0893-2336 ISSN 1940-6045 (electronic) Neuromethods ISBN 978-1-4939-6916-6 ISBN 978-1-4939-6918-0 (eBook) DOI 10.1007/978-1-4939-6918-0 Library of Congress Control Number: 2017937544 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Cover illustration: Jonas Marnell of Ethic Design assisted in the creation of this image. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Our understanding of how metals contribute to neural cell function and disease in the brain is rapidly evolving. A broad range of metals occur in the brain, from trace levels to bulk amounts. Methods for measuring levels of metals and imaging metal localization are diverse and often prone to pitfalls associated with a lack of experience in the factors that affect metal detection. This book brings together a well-considered selection of methods used by experienced metal researchers to aid investigators in their plans to examine metal levels or distribution in brain tissue, or brain-derived cells, and avoid many of the pitfalls that can lead to non-reproducible and artifact-prone data. Chapter topics cover the use of fluorescent metal probes, synchrotron-based X-ray microscopy, ICP-MS, laser ablatio
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