MHC Class-I Loss and Cancer Immune Escape
This book is about the escape strategies used by cancer cells to avoid the immune response of the host. The main characters of this story are the “Antigen Presenting Molecules” and the “T Lymphocytes”. The former are known as the Major Histocompatibility
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Federico Garrido
MHC Class-I Loss and Cancer Immune Escape
Advances in Experimental Medicine and Biology Volume 1151 Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy NIMA REZAEI, Tehran University of Medical Sciences, Children’s Medical Center Hospital, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Federico Garrido
MHC Class-I Loss and Cancer Immune Escape
Federico Garrido Departamento de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de las Nieves, Facultad de Medicina Universidad de Granada Granada, Spain
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-030-17863-5 ISBN 978-3-030-17864-2 (eBook) https://doi.org/10.1007/978-3-030-17864-2 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Acknowledgments
The work presented in this book summarizes decades of research focused on analyzing the expression of histocompatibility antigens in mouse and human tumors (H-2 and HLA) in the Dept. of Analisis Clinicos e Inmunologia at Hospital Universitario “Virgen de las Nieves” in Granada, Spain. I would like to acknowledge all the members of the research team for their contributions. Most importantly, I would like to thank the cancer patients in our hospital and from different European clinical and research institutions who gave their consent to analyze their tumor samples. I would like to mention Dr. Matias Perez
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