Innate Immune Regulation and Cancer Immunotherapy
There has been major growth in understanding innate immune signaling, inflammation, immune suppression and cancer immunotherapy. Innate immune regulation and cancer immunotherapy highlights emerging research about the underlying mechanisms of innate immun
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Rong-Fu Wang Editor
Innate Immune Regulation and Cancer Immunotherapy
Editor Rong-Fu Wang Baylor College of Medicine Houston, Texas 77030, USA [email protected]
ISBN 978-1-4419-9913-9 e-ISBN 978-1-4419-9914-6 DOI 10.1007/978-1-4419-9914-6 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011939215 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
1
Introduction ............................................................................................ Rong-Fu Wang
2
The Role of NKT Cells in the Immune Regulation of Neoplastic Disease .............................................................................. Jessica J. O’Konek, Masaki Terabe, and Jay A. Berzofsky
1
7
3
g d T Cells in Cancer............................................................................... Lawrence S. Lamb, Jr.
23
4
Toll-Like Receptors and Their Regulatory Mechanisms ................... Shin-Ichiroh Saitoh
39
5
Cytoplasmic Sensing of Viral Double-Stranded RNA and Activation of Innate Immunity by RIG-I-Like Receptors .......... Mitsutoshi Yoneyama and Takashi Fujita
51
6
Innate Immune Signaling and Negative Regulators in Cancer ......... Helen Y. Wang and Rong-Fu Wang
61
7
Dendritic Cell Subsets and Immune Regulation ................................. Meredith O’Keeffe, Mireille H. Lahoud, Irina Caminschi, and Li Wu
89
8
Human Dendritic Cells in Cancer ........................................................ Gregory Lizée and Michel Gilliet
121
9
Regulatory T Cells in Cancer................................................................ Tyler J. Curiel
147
10
Relationship Between Th17 and Regulatory T Cells in the Tumor Environment .................................................................... Ilona Kryczek, Ke Wu, Ende Zhao, Guobin Wang, and Weiping Zou
175
v
vi
Contents
11
Mechanisms and Control of Regulatory T Cells in Cancer ............... Bin Li and Rong-Fu Wang
195
12
Myeloid-Derived Suppressor Cells in Cancer ..................................... Wiaam Badn and Vincenzo Bronte
217
13
Myeloid-Derived Suppressive Cells and Their Regulatory Mechanisms in Cancer ......................................................................
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