Micro/Nano Cell and Molecular Sensors

This book focuses on cell- and molecule-based biosensors using micro/nano devices as transducers. After providing basic information on micro/nano cell- and molecule-based biosensors, it introduces readers to the basic structures and properties of micro/na

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ano Cell and Molecular Sensors

Micro/Nano Cell and Molecular Sensors

Ping Wang • Chunsheng Wu • Ning Hu K. Jimmy Hsia Editors

Micro/Nano Cell and Molecular Sensors

Editors Ping Wang Biosensor National Special Laboratory Department of Biomedical Engineering Zhejiang University Hangzhou, China Ning Hu Biosensor National Special Laboratory Department of Biomedical Engineering Zhejiang University Hangzhou, China

Chunsheng Wu Institute of Medical Engineering School of Basic Medical Sciences Health Science Center Xi’an Jiaotong University Xi’an, China K. Jimmy Hsia Department of Biomedical Engineering Carnegie Mellon University Pittsburg, PA, USA

The print edition is not for sale in China Mainland. Customers from China Mainland please order the print book from: Science Press. ISBN 978-981-10-1656-1 ISBN 978-981-10-1658-5 DOI 10.1007/978-981-10-1658-5

(eBook)

Library of Congress Control Number: 2016954427 © Science Press and Springer Nature Singapore Pte Ltd. 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Science+Business Media Singapore Pte Ltd.

Contents

1

Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ping Wang, Chunsheng Wu, Ning Hu, and K. Jimmy Hsia

1

2

Micro/Nano Biosensors for Living Cell and Molecule Analysis . . . . Ning Hu, Jiaru Fang, and Ling Zou

19

3

Label-Free DNA Biosensors with Field-Effect Devices . . . . . . . . . . Chunsheng Wu, Liping Du, Ling Zou, and Yulan Tian

45

4

Micro/Nano Cell-Substrate Impedance Biosensors . . . . . . . . . . . . . Yulan Tian, Ling Zou, and Ping Wang

73

5

Micro/Nano Cell Potential Biosensors . . . . . . . . . . . . . . . . . . . . . . . Jiaru Fang, Qin Wang, and Ning Hu

97

6

Micro/Nano Neuronal Network Cell Biosensors . . . . . . . . . . . . . . . 125 Liping Du, Liang Hu, and Chunsheng Wu

7

Micro/Nano Material-Based Biosensors . . . . . .