MicroRNA-148b is a potential prognostic biomarker and predictor of response to radiotherapy in non-small-cell lung cance
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ORIGINAL PAPER
MicroRNA-148b is a potential prognostic biomarker and predictor of response to radiotherapy in non-small-cell lung cancer Renfeng Wang & Fan Ye & Qiang Zhen & Tieying Song & Guoliang Tan & Weiwei Chu & Yaxiao Zhang & Baolei Lv & Xiaojian Zhao & Jiabao Liu Received: 22 February 2016 / Accepted: 7 April 2016 # University of Navarra 2016
Abstract miR-148b has been found to be aberrantly expressed in various tumor types. It has recently been reported to be involved in regulating radioresistance in non-small cell lung cancer (NSCLC) cells. However, its expression level and association with radiosensitivity in human patient samples have not been investigated. Realtime PCR was used to evaluate the expression levels of miR-148b. Χ2 test was performed to analyze the association between miR-148b expression levels and clinicopathological factors or radiosensitivity. Kaplan-Meier survival curve was constructed to estimate the overall survival (OS), and the differences in survival were compared using the log-rank test. Cox regression analysis was conducted to determine the prognostic value of miR-148b. The relative level of miR-148b was significantly decreased in
Electronic supplementary material The online version of this article (doi:10.1007/s13105-016-0485-5) contains supplementary material, which is available to authorized users. R. Wang : Q. Zhen : G. Tan : W. Chu : Y. Zhang : B. Lv X. Zhao : J. Liu (*) Department of Thoracic Surgery, The First Hospital of Shijiazhuang, 36 Fanxi Road, Chang’an District, Shijiazhuang 050011 Hebei Province, China e-mail: [email protected]
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F. Ye Department of Hyperbaric Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050000 Hebei Province, China T. Song Department of Anesthesiology, The First Hospital of Shijiazhuang, 36 Fanxi Road, Chang’an District, Shijiazhuang 050011 Hebei Province, China
NSCLC tissues compared with matched non-cancerous tissues (P < 0.0001), and it was higher in tissues of patients who are good responders compared to those who are poor responders to radiotherapy (P < 0.0001). Lower expression of miR-148b was positively associated with high tumor stage (P = 0.0407) and radioresistance (P = 0.0002), and it predicted poor survival in patients with (P = 0.0129) or without (P = 0.0094) radiotherapy treatment. miR-148b was an independent prognostic factor for NSCLC as demonstrated by Cox proportional hazards risk analysis. miR-148b may serve as a prognostic biomarker of poor survival and a novel predictor of response to radiotherapy treatment in NSCLC. Keywords NSCLC . miR-148b . Prognosis . Radioresistance
Introduction Lung cancer represents one of the most common malignant tumors and leading causes of cancer-related death worldwide [20]. Non-small cell lung cancer (NSCLC) accounts for approximately 80 % of all lung cancers and the 5-year survival rate is very poor, especially for stage III NSCLC patients treated with concurrent chemoradiotherapy [16, 20, 23]. NSCLC is associated with high mortality as the majority of patients h
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