The ultimate preoperative C-reactive protein-to-albumin ratio is a prognostic factor for survival after pancreatic cance
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uropean Journal of Medical Research Open Access
RESEARCH
The ultimate preoperative C‑reactive protein‑to‑albumin ratio is a prognostic factor for survival after pancreatic cancer resection Laura van Wijk1†, Guus W. de Klein2†, Matthijs A. Kanters1, Gijs A. Patijn2 and Joost M. Klaase1*
Abstract Background: Emerging evidence indicates that an elevated C-reactive protein-to-albumin ratio (CAR) may be associated with a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Further evidence showing that this ratio has significant prognostic value could contribute to current prediction models and clinical decision-making. Methods: Data were analysed of consecutive patients who underwent curative pancreatic resection between 2013 and 2018 and were histologically diagnosed with PDAC. We investigated the relation between the ultimate preoperative CAR and overall survival. Results: A total of 163 patients were analysed. Median overall survival was 18 months (IQR 9–36). Multivariate analysis demonstrated that a higher CAR (HR 1.745, P = 0.004), a higher age (HR 1.062, P
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