Microstructure, mechanical properties, and in vitro behavior of biodegradable Zn-1Mg-0.1Ca and Zn-1Mg-0.5Ca
- PDF / 1,821,701 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 27 Downloads / 186 Views
B I O M A T E R I A L S S Y N T H E S I S A N D CH A R A C T E R I Z A T I O N Original Research
Microstructure, mechanical properties, and in vitro behavior of biodegradable Zn-1Mg-0.1Ca and Zn-1Mg-0.5Ca Huafang Li
1
●
Chao Shen2,3 Dike Ruan2 Xiwei Liu4 Xiaokang Li3 Shuo Guo3 Zheng Guo3 ●
●
●
●
●
1234567890();,:
1234567890();,:
Received: 26 February 2020 / Accepted: 28 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract In the present study, the microstructure, mechanical properties, corrosion behavior, wettability, haemocompatibility, and cytocompatibility of the as-cast and as-rolled biodegradable Zn-1Mg-0.1Ca and Zn-1Mg-0.5Ca have been systematically investigated to evaluate their feasibility as potential biodegradable materials. The results demonstrated that the Zn-1Mg0.1Ca have significantly improved mechanical properties, with the yield strength (YS), ultimate tensile strength (UTS), and elongation of as-rolled Zn-1Mg-0.1Ca are (209.04 ± 28.31) MPa, (331.51 ± 40.06) MPa, and (35.43 ± 3.53)%, respectively. Wettability test results demonstrated that the Zn-1Mg-0.1Ca and Zn-1Mg-0.5Ca have hydrophilic surfaces that can enhance cell responses and tissue-implant interactions. The haemocompatibility evaluation showed that the hemolysis ratio of Zn-1Mg-0.1Ca have a low hemolysis ratio of 0.6%; the platelets remain sphere morphology and are not activated. High cell viability indicates the cytocompatibility of the as-rolled Zn-1Mg-0.1Ca alloy. The Zn-1Mg-0.1Ca alloy can be considered as new suitable biodegradable Zn-based alloys for further biomedical applications. Graphical Abstract
These authors contributed equally: Huafang Li, Chao Shen * Huafang Li [email protected]
1
School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China
* Xiwei Liu [email protected]
2
Department of Orthopedic Surgery, The Sixth Medical Center of PLA General Hospital, Beijing 100048, China
3
Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
4
Lepu Medical Technology Co., Ltd, Beijing 102200, China
* Zheng Guo [email protected]
88 Page 2 of 8
Journal of Materials Science: Materials in Medicine (2020)31:88
1 Introduction
2.2 Microstructure
In the past decade, biodegradable metals and alloys have been attracting more and more attentions due to their ability of fully biodegradable in human body, thus can avoid the painful and costly secondary surgery to remove the implants after tissue/function recovery, which is usually unavoidable for the conventional bioinert materials (such as 316SS, Ti and Ti-based alloys, Co-Cr alloys, etc.) [1]. Besides the early reported biodegradable Mg alloys [2–5] and Fe alloys [6–8], Zinc (Zn) has been recently considered as a novel biodegradable material due to its near-ideal degradation rate and acceptable biocompatibility [9]. Zn is the second most abundant trace metal in higher animals and affects major metabolic processes, as well as
Data Loading...
