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REPORT

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Abstract Molecularly imprinted polymers are mostly confined to laboratories and their standardized environments. Chemical sensors based on MIP are no exception to this; however, there are increasing efforts to span the gap toward technological applications and thus exposing the devices to real-life environments and thereby assessing selectivity, sensitivity, and ruggedness of the respective sensors. In some application areas this has already been successful, namely in detecting volatile organics and their mixtures, sensing pesticides in environmental water samples, in assessing oxidation processes, e.g., in engine oils, and in some applications of bioanalysis targeting both signaling molecules/drugs and whole cells, viruses, or bacteria. Here, we summarize the selected aspects for transferring MIP strategies out from lab-bench conditions and highlight some of the successful examples. Keywords MIP biosensing, MIP sensor materials, Oxidative degradation, Pesticides, Real-life matrices, Sensor arrays, Volatile organics

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Molecular Imprinting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Molecular Imprinting Strategies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.1 Bulk Imprinting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.2 Surface Imprinting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.3 Imprinted Nanoparticles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Molecular Imprinting in Chemical Sensing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Real-Life Applications of MIP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4.1 MIP Sensors in Multicomponent Environments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4.2 Pesticide MIP Sensors as an Example of Environmental Sensing . . . . . . . . . . . . . . . . . . 4.3 MIP Sensors Applications in Biosensing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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G. Mustafa and P.A. Lieberzeit (*) University of Vienna, Department of Analytical Chemistry, W€ahringer Strasse 38, 1090, Vienna, Austria e-mail: [email protected] S.A. Piletsky and M.J. Whitcombe (eds.), Designing Receptors for the Next Generation of Biosensors, Springer Series on Chemical Sensors and Biosensors (2013) 12: 167–188 DOI 10.1007/5346_2012_21, # Springer-Verlag Berlin Heidelberg 2012, Published online: 4 July 2012

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5 Commercially Available MIPs for Analytical Applications