Mission and Structure of the Deutsches Krebsforschungszentrum
The Deutsches Krebsforschungszentrum (DKFZ) was founded in 1964 on the initiative of the Heidelberg surgeon Prof. Dr. h.c. K. H. Bauer, who died in 1978 at the age of 86. It was constituted as a foundation of public law on the decision of the Government o
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Current Cancer Research 1992
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Springer-Verlag Berlin Heidelberg GmbH
Cover photo: Labaratory stilllife Photograph: Josef Wiegand
Additional material to this book can be downloaded from http://extras.springer.com. ISBN 978-3-662-11384-4 (eBook) ISBN 978-3-7985-0898-9 DOI 10.1007/978-3-662-11384-4 ISSN 0940-0745 Publisher: Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280 D-6900 Haideiberg 1 Tel.: + 62 21/42-0 Telex: 4 61 562 dkfz d Telefax:+ 6221/40 12 71 Editorial responsibility: Presse- und Öffentlichkeitsarbeit Hilke Stamatiadis-Smidt, M. A. Coordination: Elisabeth Hohensee, M. A. Co-workers: Dipi.-Biol. Susanne Glasmacher Dipi.-Biol. Eva Holtmannspötter AndreaOder Dipi.-Biol. Renate Ries Dr. phil. nat. Birgitt Sickenbarger Stefanie von Kalckreuth, akad. gepr. Übers. Prof. Dr. med. Gustav Wagner Dipi.-Biol. Frauke Werner Translation: Dipi.-Phys. Dirk Meenenga, B. Sc. Lay-out: Heidi Hnatek Photos: Josef Wiegand Photos in the research reports by the authors or by members of the statt. Figs. 2, 3, 55 Prof. Dr. Neidhard Paweletz, Division of Cell Growth and Division; Figs. 4, 15, 16,133, 141, 167,181,182,183 UlrichSoeder,Leimen; Fig. 24 with kind perrnission of Bildarchiv Preußischer Kulturbesitz, Berlin; Fig. 46 Prof. Dr. Ernst G. Jung, Mannheim; Fig. 99 Prof. Dr. Ulrich Kück, Bochum; Fig. 107 from J. lsao et al., The Three-Dimensional Structure of Canine Parvovirus and its Functionallmplications, SCIENCE 251,03/22191, S.1456ff., copyright by Springer-Verlag Berlin Heidelberg 1992 Originally published by Steinkopff Dannstadt in 1992
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Page New Approaches in Cancer Research
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Harald zur Hausen
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Mission and Structure of the Deutsches Krebsforschungszentrum
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Research
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Gell Differentiation and Gareinegenesis
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2.1 Cancer and Genes: The Case of the Pediatric Cancer Neuroblastoma
Manfred Schwab
28
2.2 Tumor Suppression in Drosophila
Bernard M. Mechler
35
2.3 The Role of cAMP-Oependent Signal Transduction for Cell-Type-Specific Gene Expression
Michael 8oshart Günther Schütz
40
2.4 ln Vitra Culture of Mammalian and Amphibian Embryonie Cells: Models for the Analysis of Gene Expression During Development and Differentiation
Angel Alonso Michael F. Trendelenburg
45
Tumor Gell Regulation
50
3.1 Development of Substitute Methods for Animal Experiments
Friedrich Marks
52
3.2 Sensitizing Multidrug Resistant Tumor Cells by Anchoring a Drug with Laser Light
Herwig Ponstingl Christof Granzow Georgios Nasioulas
56
Cancer Risk Factors and Prevention
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4.1 Diet and Cancer
Jürgen Wahrendorf Heiner Boeing Jenny Chang-Ciaude Rainer Frentzei-Beyme
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4.2 Studies on Risk Factars for Brain Studies in Adults
Brigitte Schlehofer
75
4.3 Air Pollution and Cancer Risk Epidemiologie Results and Regulatory Methods
Heiko Becher
80
Chapter
Page Maqsood Siddiqi Rudolf Preussmann
4.5 Reduced Fidelity of DNA Polymerase Replication A Reason for the Development of Cancer Cells?
Odilia Popanda Heinz Walter Thielmann
92
4.6 Cultivated Liver Cell Lines as a Mode
