Mitochondrial Dynamics and Neurodegeneration
Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process k
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A Aging, 41, 59, 72, 93–100, 202, 244 Anterograde transport, 141, 143, 145, 149, 154, 156 Apoptosis, 7, 9, 15, 23, 26, 28, 32, 34–38, 42, 49, 53, 56, 58, 71, 72, 81, 94, 109–129, 173, 176, 180, 181, 184, 207, 217, 224, 225, 243, 248 Axonal transport, 92, 139–162, 173, 175, 183, 246 B Bioenergetics, 47–63, 71, 216, 221, 223, 240 C Cell death, 7, 28, 35, 38, 58, 78, 81, 110, 112, 113, 116–120, 126–129, 180, 181, 198, 202–205, 207, 216, 217, 223–226, 248 Charcot-Marie-Tooth (CMT) disease, 24, 26, 63, 72, 124, 174–175, 178, 217, 244 D Docking, 20, 141, 142, 147, 150–153, 156, 157, 159–162 Dominant optic atrophy (DOA), 118, 124, 170–176, 178–189, 244 Dynamics, 3–17, 20, 34–42, 47–63, 69–100, 109–129, 139–162, 171, 174, 180, 182, 183, 199–208, 217–219, 222–228, 235–251 Dynamin-related protein 1 (Drp1), 12, 13, 15–17, 19, 21–25, 30–36, 39, 54–57, 61, 63, 71, 80, 84–86, 89, 90, 92, 94, 95, 111–118, 122, 124, 127–129, 157, 158, 202–204, 215–228, 243, 245, 248–250 Dynamin-related proteins (DRPs), 16, 25, 113
G Genetic screens, 13, 245 H Huntingtin (htt), 236–239, 241, 245–251 K Kinesin, 91, 92, 141–150, 156, 158–159 M Mechanoenzymes, 16, 17, 20, 28 Membranes and lipid homeostasis, 14, 31, 39–40 Membrane scission and fusion, 13, 20, 25 Mitochondria dynamics, 3–17, 20, 34–42, 47–63, 69–100, 109–129, 139–162, 171, 174, 180, 182, 183, 199–208, 217–219, 222–228, 235–251 fission, 1–42, 49, 53–57, 59, 61, 71, 72, 83, 84, 86–89, 91, 93, 94, 97, 111, 113–118, 127, 129, 156, 180, 181, 197–208, 215–228, 241–246, 248, 250 fusion, 1–42, 49, 53–63, 71, 72, 83–86, 88, 89, 91–94, 97, 112, 113, 118–121, 123–129, 157, 169–189, 201–203, 207, 217–219, 224, 225, 228, 241–246, 248–250 morphology, 11–15, 23, 24, 29, 32, 34, 71, 84–86, 90–92, 95, 111, 117, 120, 127–129, 161, 180, 199–201, 204, 205, 216, 222–224, 227, 228 quality control, 79, 84, 87, 89, 92–94, 97, 199, 206, 207 Mitochondrial complex I inhibitors, 198, 201, 203, 227
B. Lu (ed.), Mitochondrial Dynamics and Neurodegeneration, DOI 10.1007/978-94-007-1291-1, © Springer Science+Business Media B.V. 2011
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260 Mitochondrial mobility, 141, 150–159, 161, 162 Mitofusin (Mfn), 12, 15, 23, 26, 31, 33, 39, 53, 57, 58, 71, 84, 85, 119, 123–126, 128, 157, 174, 179, 183, 202, 204, 206, 217, 219, 228, 248–250 Mitofusin 2 (Mfn2), 12, 15, 17, 18, 26, 30, 36, 53–58, 61, 63, 71, 72, 85, 86, 90, 92, 111, 112, 115, 118, 123–129, 157, 173–189, 217, 219, 224, 225, 242, 244, 245, 248, 250 Mitophagy, 24, 36–38, 40, 78–100, 156, 162, 176, 187, 188, 200, 201, 203–207, 227, 228 Motor adaptor, 141, 146, 147, 150, 154, 156, 162 N Neurodegeneration, 7, 36–38, 61, 72, 78, 82, 83, 93–100, 161, 198, 199, 205–208, 215–228, 237, 244 Neurodegenerative diseases, 5, 7, 15, 37, 39, 72, 82, 98, 140, 151, 161, 162, 217, 225–228, 244 Neuronal cell death, 38, 202, 223, 226 O Optic atrophy 1 (OPA1), 11, 14, 15, 18, 20, 26–31, 36, 39, 53–58, 62, 63, 71, 72, 84, 86–90, 92, 111–113, 118–124, 126, 127, 129, 170–189, 217–219, 223, 224, 226, 228, 242, 244
Index Oxidative phosphorylation (OXPHOS), 6, 15, 37, 49, 50, 52, 56–60,
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