Modeling Cellular Systems
This contributed volume comprises research articles and reviews on topics connected to the mathematical modeling of cellular systems. These contributions cover signaling pathways, stochastic effects, cell motility and mechanics, pattern formation processe
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Frederik Graw Franziska Matthäus Jürgen Pahle Editors
Modeling Cellular Systems
Contributions in Mathematical and Computational Sciences Volume 11
Series editors Hans Georg Bock Willi Jäger Hans Knüpfer Otmar Venjakob
More information about this series at http://www.springer.com/series/8861
Frederik Graw Franziska Matthäus Jürgen Pahle •
Editors
Modeling Cellular Systems
123
Editors Frederik Graw Heidelberg University Heidelberg Germany
Jürgen Pahle Heidelberg University Heidelberg Germany
Franziska Matthäus Heidelberg University Heidelberg Germany
ISSN 2191-303X ISSN 2191-3048 (electronic) Contributions in Mathematical and Computational Sciences ISBN 978-3-319-45831-1 ISBN 978-3-319-45833-5 (eBook) DOI 10.1007/978-3-319-45833-5 Library of Congress Control Number: 2016960568 © Springer International Publishing Switzerland 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
The life of multicellular organisms, such as humans and animals, is a complex dynamic process requiring the constant interaction of various molecules, cells, organs and other factors within the organism itself, and in exchange with the environment. In the human body, each cell has its specific task that is necessary to enable us to walk, breath, produce energy or fight infections. Only the tight regulation of multiple processes on various scales, be it on the genetic, molecular or cell population level, leads to the proper functioning of the complete system. Each cell on its own also represents a complex, multi-scale system that receives, processes and transmits information by cellular signalling, the production of enzymes and proteins, or by adapting their mechanical properties or cell cycle dynamics. While, step by step, we learn more and more about individual elem
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