Mathematical Modeling of Biological Systems, Volume I Cellular Bioph
This two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. Highlighted throughout both works are mathematical and computat
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Mathematical Modeling of Biological Systems, Volume I Cellular Biophysics, Regulatory Networks, Development, Biomedicine, and Data Analysis
Andreas Deutsch Lutz Brusch Helen Byrne Gerda de Vries Hanspeter Herzel Editors
Mathematical Modeling of Biological Systems, Volume I Cellular Biophysics, Regulatory Networks, Development, Biomedicine, and Data Analysis
Andreas Deutsch Lutz Brusch Helen Byrne Gerda de Vries Hanspeter Herzel Editors
Birkh¨auser Boston • Basel • Berlin
Andreas Deutsch Center for Information Services and High Performance Computing Technische Universit¨at Dresden 01062 Dresden Germany
Lutz Brusch Center for Information Services and High Performance Computing Technische Universit¨at Dresden 01062 Dresden Germany
Helen Byrne Centre for Mathematical Medicine School of Mathematical Sciences University of Nottingham Nottingham NG7 2RD U.K.
Gerda de Vries Department of Mathematical and Statistical Sciences University of Alberta Edmonton, AB T6G 2G1 Canada
Hanspeter Herzel Institute of Theoretical Biology Humboldt-Universit¨at zu Berlin Invalidenstraße 43 10115 Berlin Germany
Mathematics Subject Classification: 00A71, 37N25, 46N60, 47N60, 62P10, 76Zxx, 78A70, 92-XX, 92Bxx, 92B05, 92Cxx, 92C05, 92C15, 93A30 Library of Congress Control Number: 2007920791 ISBN-13: 978-0-8176-4557-1
e-ISBN-13: 978-0-8176-4558-8
Printed on acid-free paper. c 2007 Birkh¨auser Boston All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Birkh¨auser Boston, c/o Springer Science+Business Media LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights.
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Preface
This edited volume contains a selection of chapters that are an outgrowth of the European Conference on Mathematical and Theoretical Biology (ECMTB05, Dresden, Germany, July 2005). The peer-reviewed contributions show that mathematical and computational approaches are absolutely essential for solving central problems in the life sciences, ranging from the organizational level of individual cells to the dynamics of whole populations. The contributions indicate that theoretical and mathematical biology is a diverse and interdisciplinary field, ranging from experimental research linked to mathematical modeling to the development of more abstract mathematical frameworks in which observations about the real world can be interpreted, and with which new hypotheses for testing can be generated. Today, much attention is also paid to the development o
